Results 141 to 150 of about 3,463,591 (310)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Global Climate Change: Impact and Remediation [PDF]

This "clicker case" is a continuation of another case study "Global Climate Change: Evidence and Causes". Students assume the role of an intern working for a U.S.
Maureen Knabb, Timothy Lutz
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Enhancing 8th grade students’ environmental science competency through science, technology, society, and environment-oriented teaching: an experimental study

Discover Education
Against the backdrop of increasing global environmental challenges, enhancing environmental science competency for students is a key educational objective, yet traditional methods often fail to connect knowledge with practice.
Nguyen Quang Linh, Nguyen Thi Hang, Tran Quang Hieu   +2 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Documents for the history of the oldest Brazilian zoological park: the Goeldi museum zoobotanical park

Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas, 2012
The paper contextualizes the creation of the Goeldi Museum Zoobotanical Park, in Belém, State of Pará, in 1895, considered the oldest zoo in Brazil.
José de Sousa e Silva Junior, Nelson Sanjad, David Conway Oren, Horácio Higuchi, Marinus Steven Hoogmoed   +4 more
doaj  

A systematic review of internet-based worksite wellness approaches for cardiovascular disease risk management: outcomes, challenges & opportunities. [PDF]

, 2014
ContextThe internet is gaining popularity as a means of delivering employee-based cardiovascular (CV) wellness interventions though little is known about the cardiovascular health outcomes of these programs.
Agatston, Arthur S, Al-Mallah, Mouaz H, Aneni, Ehimen C, Blaha, Michael J, Blankstein, Ron, Blumenthal, Roger S, Budoff, Matthew J, Feldman, Theodore, Maziak, Wasim, Nasir, Khurram, Roberson, Lara L, Rouseff, Maribeth, Tran, Thinh H   +12 more
core  

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

GLOBE Observer: A Case Study in Advancing Earth System Knowledge with AI-Powered Citizen Science

Citizen Science: Theory and Practice
Citizen science and artificial intelligence (AI) complement each other by harnessing the strengths of both human and machine capabilities. Citizen science generates terabytes of raw numerical, text, and image data, the analysis of which requires ...
Peder V. Nelson, Russanne Low, Holli Kohl, David Overoye, Di Yang, Xiao Huang, Sriram Chellappan, Farhat Binte Azam, Ryan M. Carney, Monika Falk, Joan Garriga, Larisa Schelkin, Rebecca Boger, Theresa Schwerin   +13 more
doaj   +1 more source