Results 81 to 90 of about 741,789 (265)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Citizen science projects related to Chemistry and Biology education: a systematic review

Frontiers in Education
IntroductionCitizen science is a participatory approach that enables the general population to collaborate in scientific research projects. In many cases, it is connected to Chemistry and Biology to address environmental, health, and educational ...
Carmen Viviana Basantes-Vaca, Luis Alberto Mera-Cabezas, Paulina Fernanda Parra-Alvarez, Estefanía Nataly Quiroz-Carrión, Celso Vladimir Benavides-Enríquez   +4 more
doaj   +1 more source

A Typology of Indigenous Engagement in Australian Environmental Management: Implications for Knowledge Integration and Social-ecological System Sustainability

Ecology and Society, 2012
Indigenous peoples now engage with many decentralized approaches to environmental management that offer opportunities for integration of Indigenous Ecological Knowledge (IEK) and western science to promote cultural diversity in the management of social ...
Rosemary Hill, Chrissy Grant, Melissa George, Catherine J. Robinson, Sue Jackson, Nick Abel   +5 more
doaj   +1 more source

INTEGRATED ENVIRONMENTAL HEALTH IMPACT ASSESSMENT AT THE SCIENCE-POLICY INTERFACE: GENERATING POLICY-RELEVANT KNOWLEDGE

ISEE Conference Abstracts, 2011
Background and Aims: The study explores which science-policy activities have been undertaken in the case studies of two EU consortium projects funded under the EU 6th Framework Programme: INTARESE ...
EM Kunseler, AB Knol
openaire   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Method for long-term room temperature storage of mouse freeze-dried sperm

Scientific Reports
Permanent preservation of genetic resources may be indispensable for the future of humanity. This requires liquid nitrogen, as is the case for preserving animal sperm.
Yuko Kamada, Kango Yamaji, Natsuki Ushigome, Daiyu Ito, Sayaka Wakayama, Kenichiro Hiraoka, Masaru Hayashi, Kiyotaka Kawai, Teruhiko Wakayama   +8 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Intermediary Effect of Digital Economy on Impact of the Fiscal Revenue and Expenditure Structure on Dual-Circulation Development Paradigm

International Journal of Crowd Science
In the context of dual-circulation development paradigm and high-quality economic growth in full swing, it is crucial to adjust the structure of fiscal revenue and expenditure to drive the crowd intelligence-driven digital economy’s development. From the
Yan Zhao, Xiaoya Kong, Jing Yang, Piotr Felisiak   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source