Results 31 to 40 of about 1,889,708 (301)

Collateralized Assets Prices and Monetary Policy

open access: yesRevista de Economía del Rosario, 2019
A well-informed and cautious financial system can improve the welfare outcome of an economy by making lenders surplus to borrowers. Nevertheless, in a crisis, the behavior of the financial system can become an amplifier of it, given that credit approval ...
Mauricio Arango
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Optimal Portfolio Choice in a General Equilibrium Model with Portfolio Frictions and Short-Selling Constraint

open access: yesMathematics
Recent developments in dynamic portfolio optimization have focused on the role played by portfolio frictions. Portfolio frictions make the portfolio’s response to financial shocks weaker and more gradual than in a model without frictions.
Simon Tièche, Didier Cossin
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Optimal level of demand and supply public goods in the general equilibrium model with Lindahl tax [PDF]

open access: yesمدلسازی اقتصادسنجی, 2017
In the real world, there are commodities that although consumers are willing to pay for them, but they cannot obtain them by market. These goods are public goods that all people will benefit from their use, and about them so-called market fails.
Majid Maddah   +2 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

OPTIMAL CONGESTION CHARGES IN GENERAL EQUILIBRIUM

open access: yesIATSS Research, 2002
This paper deals with pricing and investment decision problems of multi-route and multi-period highway systems in which the congestion is a significant factor in the assessment of system costs.
Dong-Joo MOON, Ph.D.
doaj   +1 more source

Transação de Créditos REDD em Mercados Internacionais de Carbono

open access: yesNotas Económicas, 2023
While several economic studies have looked into the role of REDD in climate policy, the interlinks between climate policy, international trade and agricultural markets have been only marginally considered.
Renato Rosa   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

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