Results 41 to 50 of about 437,926 (308)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Capital Flow and Bank Lending Channels in a Small Open Economy: Evidence from Indonesia
Buletin Ekonomi Moneter dan PerbankanThis paper investigates the implication of macro-financial linkages to explain the interaction of the financial and business cycles as the primary contributor to understanding the fluctuations in the Indonesian economy.
Advis Budiman +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A Spatial Computable General Equilibrium Model [PDF]
, 1993 We present a spatial computable general equilibrium model for which the Walras' law is employed to articulate the general equilibrium of a spatially separated economy while Wardrop's first principle is used to enuniciate the flow equilibrium on a general
Westin, Lars, +2 more
core
برنامهریزی و بودجه, 2021 The concept of rational behavior has a significant role in economics and its analysis of market economy and general equilibrium. On the other hand, there exists a logical relation between limits of rationality and learning from error. With explaining the
Masoud Mohammadi Alamuti
doaj
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Laffer Curve and Taxable Revenue Elasticity: The Impact of Tax Deductions on a Dynamic General Equilibrium Model [PDF]
پژوهشهای اقتصادیAim and Introduction Making changes in the tax system is one of the basic and important needs for increasing government tax revenues. To achieve this, the tax system must move in a direction that increases the tax base.
Nahid Gohartash +4 more
doaj
Impacts of Direct and Indirect Tax Reforms in Vietnam: A CGE Analysis
Economies, 2019 The study applies a multi-sector multi-household static computable general equilibrium (CGE) tax model to assess the economy-wide impacts of taxes in Vietnam.
Keshab Bhattarai +2 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source