Results 61 to 70 of about 1,889,708 (301)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Potential Implications of the Pandemic on Medium Term Productivity

Buletin Ekonomi Moneter dan Perbankan
This study analyses the potential medium-term impact of the pandemic to productivity and macroeconomy. It simulates the impact of the pandemic on productivity, labor and macroeconomic dynamics.
Pakasa Bary, Pandu Kuntoaji, Dwi Multiretno, IGP Wira Kusuma   +3 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

From General Equilibrium to Algorithmic Equilibrium

Qeios, 2023
Based on the Algorithmic Thinking Theory, this essay introduces the concept of “Algorithmic Equilibrium”, which can really exist and be used to replace, re-interpret, and/or synthesize all other kinds of equilibria, and to allow the coexistence of equilibria and various dis-equilibria in a unified, dynamic, and developmental panorama, thus exhibiting a
openaire   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Banking in General Equilibrium [PDF]

This paper attempts to provide a step towards understanding the role of financial intermediaries ("banks") in aggregate economic activity. We first develop a model of the intermediary sector which is highly simplified, but rich enough to motivate several
Ben S. Bernanke, Mark L. Gertler
core  

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Impactos da política americana de estímulo aos biocombustíveis sobre a produção agropecuária e o uso da terra

Revista de Economia e Sociologia Rural, 2011
O presente estudo estima os impactos do crescimento da demanda de etanol no Brasil e nos EUA sobre a produção agrícola e o uso da terra. Utiliza-se um modelo econômico global capaz de representar os mercados agropecuários e de energia, as relações ...
Angelo Costa Gurge
doaj   +1 more source

Inventories and the Stockout Constraint in General Equilibrium [PDF]

, 2013
We study the implications of a stockout constraint in a dynamic general equilibrium model, which can explain both standard business cycle and inventory facts.
Bencivenga, Bencivenga, Bernanke, Bernanke, Bils, Bils, Bils, Bils, Bjork, Bjork, Boileau, Boileau, Christiano, Christiano, Fisher, Fisher, Fitzgerald, Fitzgerald, Gertler, Gertler, Hornstein, Hornstein, Jagjit S. Chadha, Kahn, Kahn, Kahn, Kahn, Kahn, Kahn, Kashyap, Kashyap, Katsuyuki Shibayama, Khan, Khan, Khan, Khan, Kitchin, Kitchin, Kryvtsov, Kryvtsov, Kryvtsov, Kryvtsov, Maccini, Maccini, Marchetti, Marchetti, Martins, Martins, Metzler, Metzler, Ramey, Ramey, Rotemberg, Rotemberg, Schumpeter, Schumpeter, Wright, Wright   +57 more
core   +2 more sources

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source