Results 111 to 120 of about 7,663,513 (304)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
General Covariance and Background Independence in Quantum Gravity [PDF]
, 2012 The history of general relativity suggests that in absence of experimental data, constructing a theory on philosophical first principles can lead to a very useful theory as well as to ground-breaking insights about physical reality.
Bärenz, Manuel
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
, 2018 This year the General Editors continued the tradition started last year by creating a feature piece to show our appreciation for the History Department.
Bamba, Abou B. +3 more
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Mashhadis and Immigration: Redemptive Narratives and Practical Challenges
ReligionsThis paper analyzes redemptive narratives constructed by Mashhadi Jewish immigrants through oral histories, memoirs, and life stories collected across generations. It examines how conceptions of religion, community, and family shaped their meaning-making
Hilda Nissimi
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Вестник Мининского университета, 2017 The paper is dedicated on detail consideration of two types of John of Salisbury’s works (1115/1120-1180) - the big one including treatises “Entheticus de dogmate philosophorum”, “Policraticus”, “Metalogicon” and the small one, which involves two "Lifes"
A. K. Gladkov
doaj +2 more sources
REVIEW to: Francisco Gómez Martos, La creación de una historia nacional. Juan de Mariana y el papel de la Antigüedad en la Edad Moderna, Madrid: Dykinson, 2018, pp. 272 (ISBN 978-8491485476) [PDF]
Talia dixit, 2018 Review to La creación de una historia nacional. Juan de Mariana y el papel de la Antigüedad en la Edad Moderna (Anejos de la Revista de Historiografía nº 8).
Joaquín Villalba Álvarez
doaj
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source