Results 91 to 100 of about 7,663,513 (304)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Newspaper “Rech” in the July Crisis of 1914
Vestnik MGIMO-Universiteta, 2014 This article examines the position of the newspaper "Rech" during the July crisis of 1914. "Rech", founded in 1906 by the Constitutional Democratic Party (Kadets), was on the eve of the First World War one of the most important liberal organs of the ...
B. S. Kotov
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
, 1958 Vastly increased research and a sounder technique in history in the nineteenth century had two influences on the social sciences. When an enthusiasm for the records of history was combined with the evolutionary perspective, it often resulted in the ...
Bloom, Robert L. +6 more
core
Reconstructing the Star Formation History of the Galaxy
, 2000 The evolution of the star formation rate in the Galaxy is one of the key ingredients quantifying the formation and determining the chemical and luminosity evolution of galaxies.
CC Lin +7 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Descolonizar a história: epistemologia disruptiva
Contemporânea, 2020 As estruturas discursivas que se encarregam da reconstituição da experiência antiga e contemporânea dos africanos e dos descendentes de africanos no mundo permanecem marcadas pelas convenções da escrita colonial.
Martial Ze Belinga
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Sexual health in general practice: history and the partner history [PDF]
Journal of Family Planning and Reproductive Health Care, 2011 The 50th anniversary of the contraceptive pill has been much discussed, and women of the generation that obtained ‘the pill’ in its earliest days have been telling how they had to pretend they were married or had a fiance. A brief fictionalised account of this era was given in one of the earliest episodes of the nuanced television series, Mad Men ...
openaire +2 more sources