Results 81 to 90 of about 7,663,513 (304)

Archaeology of Ancient Israelite Religion(s): An Introduction

open access: yesReligions, 2020
Israelite religion has always fascinated scholars [...]
Avraham Faust
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Nigeria’s democracy: the trilemma of herdsmenism, terrorism and vampirism

open access: yesInkanyiso, 2017
Since the ‘invention’ of democracy by the Greek City States in the first half of the 5th Century B.C. and its popularisation after the American War of Independence in the 17th century, democracy has remained the most famous form of government.
Emmanuel O. Ojo
doaj   +1 more source

Men with intellectual disabilities with a history of sexual offending: empathy for victims of sexual and non-sexual crimes [PDF]

open access: yes, 2014
Background: The objectives were (a) to compare the general empathy abilities of men with intellectual disabilities (IDs) who had a history of sexual offending to men with IDs who had no known history of illegal behaviour, and (b) to determine whether men
Baron-Cohen   +82 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

STIMULUS GENERALIZATION OF BEHAVIORAL HISTORY [PDF]

open access: yesJournal of the Experimental Analysis of Behavior, 2003
Undergraduates responded under a variable‐ratio 30 schedule in the presence of a 25‐mm long line and on a differential‐reinforcement‐of‐low‐rate 6‐s schedule when a 13‐mm long line was present. Following this, a line‐length continuum generalization test was administered under a fixed‐interval 6‐s schedule (Experiment 1) or extinction (Experiment 2). In
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Oregon Relishes Burgundian Influence [PDF]

open access: yes, 2007
Rusty Gaffney gives a year-by-year look at Oregon vintages and a general overview of Willamette Valley wine history in this article from his Prince of Pinot blog, volume 6, issue 36.
Gaffney, William Rusty
core   +1 more source

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