Results 131 to 140 of about 1,299,612 (309)

Special Issue Introduction: Teaching the General Linear Model

Journal of Methods and Measurement in the Social Sciences, 2015
Rafael Antonio Garcia, Melinda F Davis
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Comparative Study of Delay Discounting Rates in Alcohol and Opioid Dependence in Northern India

Indian Journal of Community Medicine
Background: The study of delay discounting (DD) in addictive disorders helps in understanding why an individual chooses addictive substances immediately over possible long-term gains.
Md Abdus Sabir, Ravindra Rao, Ashwani Kumar Mishra, Rachna Bhargava, Atul Ambekar   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Towards understanding the antagonistic activity of phytic acid against common foodborne bacterial pathogens using a general linear model. [PDF]

PLoS One, 2020
Boukhris I, Smaoui S, Ennouri K, Morjene N, Farhat-Khemakhem A, Blibech M, Alghamdi OA, Chouayekh H.   +7 more
europepmc   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Linear models, smooth transition autoregressions and neural networks for forecasting macroeconomic time series: A reexamination [PDF]

In this paper we examine the forecast accuracy of linear autoregressive, smooth transition autoregressive (STAR), and neural network (NN) time series models for 47 monthly macroeconomic variables of the G7 economies.
Timo Teräsvirta, Marcelo Cunha Medeiros, Dick van Dijk   +2 more
core  

Tourism Competitiveness and Mobile Data: A Grey Relational Analysis for European Entrepreneurship Pre & During Pandemic

ECONOMICS
The tourism country’s competitiveness is important especially when countries strive for bigger market shares as European countries are. The COVID-19 pandemic has had devastating effects on tourism and the entire tourism industry must be rethinking and ...
Gabor Manuela Rozalia, Curta Petru Alexandru, Oltean Flavia Dana   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Bayesian outliers functions for linear models. [PDF]

This paper introduces two new diagnostic tools: the Bayesian outlier curve (BOC) and the Sequential Bayesian outlier curve (SEBOC). Both are built using the posterior odds for every possible number of outliers in a scale contaminated linear model.
Tíao, George C., Peña, Daniel
core