Results 151 to 160 of about 14,798,231 (416)
Clinical commissioning of an adaptive radiotherapy platform: Results and recommendations
Abstract Online adaptive radiotherapy platforms present a unique challenge for commissioning as guidance is lacking and specialized adaptive equipment, such as deformable phantoms, are rare. We designed a novel adaptive commissioning process consisting of end‐to‐end tests using standard clinical resources.
Kelly Kisling+5 more
wiley +1 more source
Incidence of professional stress and burnout syndrome in general physicians [PDF]
Introduction: Professional stress and burnout syndrome are widely spread among health professionals. Objective: Examine the incidence of professional stress in general physicians (GPs) and the risk of burnout syndrome. Method: A cross-sectional study was
Petrov-Kiurski Miloranka Đ.
doaj
A study on the attitudes of foundation doctors in Malta towards general practice and their experience while working in the specialty [PDF]
Introduction: A substantial number of Foundation year (FY) doctors have a three month rotation in family medicine at the health centres in Malta. The aim of the study was to understand the factors that influence FY doctors’ attitudes towards general ...
Abela, Jurgen, Baldacchino, Marilyn
core
High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]
BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E.+12 more
core +1 more source
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren+4 more
wiley +1 more source
Abstract Background Ultrasonography (US) and 99mTechnetium‐sestamibi scintigraphy (99mTc‐MIBI) are currently first‐line imaging modalities to localize parathyroid adenomas with sensitivities of 80% and 84%, respectively. Therefore, finding other modalities to further improve the diagnostic accuracy for preoperative localization is critically needed ...
Fangyi Liu+7 more
wiley +1 more source
The use of next-generation sequencing in personalized medicine [PDF]
The revolutionary progress in development of next-generation sequencing (NGS) technologies has made it possible to deliver accurate genomic information in a timely manner. Over the past several years, NGS has transformed biomedical and clinical research and found its application in the field of personalized medicine.
arxiv
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh+6 more
wiley +1 more source
Q fever outbreak in the terraced vineyards of Lavaux, Switzerland
Abstract Coxiella burnetii infection (Q fever) is a widespread zoonosis with low endemicity in Switzerland, therefore no mandatory public report was required. A cluster of initially ten human cases of acute Q fever infections characterized by prolonged fever, asthenia and mild hepatitis occurred in 2012 in the terraced vineyard of Lavaux ...
C. Bellini+9 more
wiley +1 more source
Statistical process control to monitor use of a web‐based autoplanning tool
Abstract Purpose To investigate the use of statistical process control (SPC) for quality assurance of an integrated web‐based autoplanning tool, Radiation Planning Assistant (RPA). Methods Automatically generated plans were downloaded and imported into two treatment planning systems (TPSs), RayStation and Eclipse, in which they were recalculated using ...
Hunter Mehrens+5 more
wiley +1 more source