Results 71 to 80 of about 801,837 (233)
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Diagnosis and Treatment Protocol for COVID-19 Patients (Tentative 9th Version)
Infectious Diseases & Immunity, 2022 The General Office of National Health Commission & the General Office of National Administration of Traditional Chinese Medicine +1 more
doaj +1 more source
Functional neurological disorder mimicking stroke: A case report
Clinical Case ReportsKEY CLINICAL MESSAGE Even in the era of technology‐guided medicine, the clinician must integrate into his daily practice a careful anamnesis and physical examination to be conducted within a close doctor–patient relationship. All these elements, together
G. Venturini, C. Sarti
doaj +1 more source
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Clinical Case ReportsAcute disseminated encephalomyelitis can present with brainstem symptoms and bilateral symmetrical lesions in the basal ganglia. In such cases, differentiation from chronic lymphocytic inflammation with pontine perivascular enhancement responsive to ...
Masahiko Ezoe +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Internal Assessment of Isfahan General Medicine Curriculum Based on Basic standards of Ministry of Health and Medical Education: A Model for Evaluation and Analysis of Results [PDF]
مجله ایرانی آموزش در علوم پزشکی, 2011 Introduction: Necessity for promotion of education quality in course of medicine forced the educational authorities including those of Isfahan school of Medicine to take actions towards promotion of education using an accreditation evaluation model in ...
Mostafa Dehghani Poudeh +6 more
doaj
Journal of the Royal Army Medical Corps, 2004 A J, Moore, M, Dayer, E, Swallow
openaire +2 more sources
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source