Results 91 to 100 of about 4,061,047 (303)

Gastric Trichobezoar: A Case Report of a Young Adult From a Secondary Hospital

Clinical Case Reports
Key Clinical Message Trichobezoar is the pathological formation of a hair mass within the gastrointestinal tract, usually correlated with psychiatric conditions like trichotillomania and trichophagia.
Mohaned Altijani Abdalgadir Hamdnaalla, Mohammed Ali Mohammed Ali, Eltayeb Sabeil Abdalla Idris, Maisara Fathi Ahmed Salih, Heyam Abdelazim Abdelrahim Ali, Rame Taha Zeiada Taha, Loai Osman Elrofaie Osman   +6 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The Interconnected Factors of Emotional Regulation, Trauma, and Substance Use in Non‐Suicidal Self‐Injury: A Case Study and Literature Review

Clinical Case Reports
Non‐suicidal self‐injury (NSSI) is a complex and often misunderstood behavior linked to emotional dysregulation, trauma, and substance use. In this case report we present a 19‐year‐old female with a history of childhood trauma and substance use, who ...
Sakshi Prasad, Diana Sofia Galarza, Vasudha Sharma, Saad Ather, Wafa Sosal, Amina Hanif, Sasidhar Gunturu, Souparno Mitra   +7 more
doaj   +1 more source

Future Research in General Medicine Has Diverse Topics and is Highly Promising: Opinions Based on a Questionnaire Survey

International Journal of General Medicine, 2022
Masaki Tago,1 Risa Hirata,1 Takashi Watari,2 Kiyoshi Shikino,3 Yosuke Sasaki,4 Hiromizu Takahashi,5 Taro Shimizu6 1Department of General Medicine, Saga University Hospital, Saga, Japan; 2General Medicine Center, Shimane University Hospital, Shimane ...
Tago M, Hirata R, Watari T, Shikino K, Sasaki Y, Takahashi H, Shimizu T   +6 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Peptic Ulcer: Rise and fall

, 2002
Consists of the edited transcripts of Witness Seminars organized by the History of Twentieth Century Medicine Group and held at the Wellcome Institute for the History of Medicine,London, on 12 May 2000.
Christie, DA, Tansey, EM
core  

Ghost-Managed Medicine

, 2018
Ghost-Managed Medicine by Sergio Sismondo explores a spectral side of medical knowledge, based in pharmaceutical industry tactics and practices. Hidden from the public view, the many invisible hands of the pharmaceutical industry and its agents channel ...
Sergio Sismondo
core   +1 more source

A Brainstem‐Dominant Acute Disseminated Encephalomyelitis Presenting With Magnetic Resonance Imaging Findings Similar to Those of Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroid Syndrome

Clinical Case Reports
Acute disseminated encephalomyelitis can present with brainstem symptoms and bilateral symmetrical lesions in the basal ganglia. In such cases, differentiation from chronic lymphocytic inflammation with pontine perivascular enhancement responsive to ...
Masahiko Ezoe, Risa Hirata, Masafumi Kosugi, Masaki Tago   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source