Results 101 to 110 of about 16,973,530 (253)

Boston University School of Medicine catalog [PDF]

open access: yes, 1890
Course catalog and informational material for the Boston University School of ...
Boston University School of Medicine
core  

A Brainstem‐Dominant Acute Disseminated Encephalomyelitis Presenting With Magnetic Resonance Imaging Findings Similar to Those of Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroid Syndrome

open access: yesClinical Case Reports
Acute disseminated encephalomyelitis can present with brainstem symptoms and bilateral symmetrical lesions in the basal ganglia. In such cases, differentiation from chronic lymphocytic inflammation with pontine perivascular enhancement responsive to ...
Masahiko Ezoe   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Boston University School of Medicine catalog [PDF]

open access: yes, 1887
Course catalog and informational material for the Boston University School of ...
Boston University School of Medicine
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Boston University School of Medicine catalog [PDF]

open access: yes, 1874
Course catalog and informational material for the Boston University School of ...
Boston University School of Medicine
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Boston University School of Medicine catalog [PDF]

open access: yes, 1907
Course catalog and informational material for the Boston University School of ...
Boston University School of Medicine
core  

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