Advanced Science, EarlyView.This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian +10 more
wiley +1 more source
RBF-assisted surrogate modeling and machine learning for mechanical property prediction in friction stir additive manufacturing: Application to dissimilar AA6061/AA7075 aluminum alloys. [PDF]
Sci RepVenkatachalam K +4 more
europepmc +1 more source
Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature
Advanced Science, EarlyView.A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo +14 more
wiley +1 more source
Construction and validation of a prognostic prediction model for critically ill lung cancer patients based on respiratory functional reserve and systemic inflammatory characteristics. [PDF]
Am J Cancer ResSun Y, He J, Luo X, Sun G, Tao X, Gan W.
europepmc +1 more source
Advanced Science, EarlyView.Conventional single‐gradient freeze‐casting typically produces unidirectional porous architectures with limited transverse connectivity. The Sequential Hybridization by Infiltration and Freeze‐casting Technique (SHIFT) addresses this constraint by integrating secondary aligned structures within a preformed primary scaffold.
Kiho Sung, Sungchul Shin
wiley +1 more source
Machine‐Learning Framework for Designing Stable Interfaces in All‐Solid‐State Lithium‐Ion Batteries
Advanced Science, EarlyView.A data‐driven strategy is developed to discover coating materials for all‐solid‐state lithium batteries. Using calculations of interfacial reactivity, unsupervised pattern recognition, and machine‐learning prediction, the study identifies low‐reactivity compositional patterns and screens new lithium‐based oxide and polyanion candidates, extending ...
Sehyeok Park +4 more
wiley +1 more source
WebGWAS: a web server for instant GWAS on arbitrary phenotypes. [PDF]
BioData MinZietz M +3 more
europepmc +1 more source
Multiscale Circuit Architecture Associated With Memory Dysfunction in Temporal Lobe Epilepsy
Advanced Science, EarlyView.A multiscale precision‐mapping framework reveals that memory impairment in temporal lobe epilepsy arises from the convergence of focal medial temporal pathology, strategic white matter disconnection, and limbic‐centered metabolic network dysfunction.
Jiajie Mo +12 more
wiley +1 more source
Artificial intelligence approaches in biological age prediction: current status and challenges. [PDF]
Br J Biomed SciWang G +9 more
europepmc +1 more source
High Tree Species Diversity Promotes Thermal Enhancement Response of Microbial Carbon Use Efficiency
Advanced Science, EarlyView.ABSTRACT Predicting soil carbon dynamics under warming is constrained by limited understanding of microbial thermal adaptation, particularly whether microbial carbon use efficiency (CUE) can adapt to warming and how plant diversity modulates this response. Using soils from a natural tree species diversity gradient in a subtropical forest, we combined a
Pengpeng Duan +11 more
wiley +1 more source