Results 231 to 240 of about 8,118,969 (359)

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Amyotrophic Lateral Sclerosis Prevalence Projection in 2040: A Less Rare Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To project ALS prevalence across multiple countries through 2040, accounting for both population aging and increased survival. Methods Data from the Piemonte and Valle d'Aosta ALS register (PARALS) was used to estimate the trends in incidence and prevalence from 2005 to 2019. Survival trends over this period were also assessed.
Rosario Vasta, Stefano Callegaro, Antonio Canosa, Umberto Manera, Maurizio Grassano, Francesca Palumbo, Sara Cabras, Enrico Matteoni, Francesca Di Pede, Filippo De Mattei, Salvatore Tafaro, Neil M. Thakur, Ryan Grosenick, Fabiola De Marchi, Letizia Mazzini, Cristina Moglia, Andrea Calvo, Kuldip D. Dave, Adriano Chiò   +18 more
wiley   +1 more source

Addressing systemic workforce challenges in general practice-a qualitative study of general practitioners in Ireland. [PDF]

Fam Pract
Shabbir U, O'Connor R, MacDonagh J, O'Regan A.   +3 more
europepmc   +1 more source

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

Mobilising Knowledge for General Practice Decarbonisation: Maximising Impact Through a Multi-Stakeholder Workshop. [PDF]

Health Expect
Nunes AR, Geddes O, Karaba F, Eccles A, Twohig H, Atherton H, Dahlmann F, Gregg M, Spencer R, Dale J.   +9 more
europepmc   +1 more source

Towards best practice recommendations: Perspectives from Australian GPs to inform the use of general practice data for research – A modified Delphi study

Heidi R. Green, Lucy Carolan, Chris Degeling, Carolyn Adams, Felicity Flack, Lucy Carolan, Belinda Fabrianesi, Anthony Scott Brown, Alberto Nettel Aguirre, Allison Clarke, Christian Jung, Annette Braunack-Mayer   +11 more
openalex   +1 more source

Determinants of Quality of Life of Elderly Patients Attending a General Practice Clinic in Southwest Nigeria [PDF]

, 2018
Oladipupo Omolade Fakoya, Emmanuel Akintunde Abioye-Kuteyi, Ibrahim Sebutu Bello, Olarenwaju O. Oyegbade, Samuel Anu Olowookere, I.T. Ezeoma   +5 more
openalex   +1 more source

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source

Referee report. For: How can medical schools create the general practice workforce? An international perspective [version 1; peer review: awaiting peer review]

, 2020
David Bruce
openalex   +1 more source

The wrong diagnosis: identifying causes of potentially adverse events in general practice using incident monitoring [PDF]

, 1998
Alice L Bhasale
openalex   +1 more source