Results 91 to 100 of about 6,965 (284)
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
The Philosophy of Taking Conspiracy Theories Seriously [PDF]
, 2019 During the last few decades, the proliferation of interest in conspiracy theories became a widespread phenomenon in our culture, and also in academia.
Freiman, Ori
core
Effect of multiple disturbances on food web vulnerability to biodiversity loss in detritus-based systems [PDF]
, 2015 Global biodiversity is affected by human pressure and climate change, and the present rate of biodiversity loss is probably higher than ever before. Community composition is also changing, and interspecific interactions are under severe pressure.
Calizza, Edoardo +2 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Altruism and the evolution of resource generalism and specialism [PDF]
, 2012 The evolution of resource specialism and generalism has attracted widespread interest. Evolutionary drivers affecting niche differentiation and resource specialization have focused on the role of trade-offs.
Abrams +72 more
core +2 more sources
Generic generalized diagonal matrices
Journal of AlgebraGeneralized diagonal matrices are matrices that have two ladders of entries that are zero in the upper right and bottom left corners. The minors of generic generalized diagonal matrices have square-free initial ideals. We give a description of the facets of their Stanley-Reisner complex.
Nguyen, Vinh, Simper, Hunter
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Where next for university teaching improvement? What the Scottish example of quality enhancement has to offer [PDF]
, 2014 No abstract ...
Gunn, Vicky
core
Enhancing the quality and safety of care through training generalist doctors: a longitudinal, mixed-methods study of a UK broad-based training programme [PDF]
, 2018 Objective Changing patient demographics make it ever more challenging to maintain the quality and safety of care. One approach to addressing this is the development of training for generalist doctors who can take a more holistic approach to care.
Allery, Lynne +5 more
core +2 more sources