Results 111 to 120 of about 3,776 (284)
Programme evaluation of the general internal medicine training programme
Future Healthcare JournalGeneral internal medicine (GIM) has predominantly been perceived as a joint specialty to be completed alongside specialty training in the United Kingdom.
Elizabeth Estabrook +2 more
doaj +1 more source
, 2023 The goal of this paper is to present an approach to Hod Pair Capturing (HPC). $HPC$ is the most outstanding open problem of descriptive inner model theory. More specifically, we introduce two principles, the Direct Limit Independence and the Bounded Direct Limits, and show that they together imply HPC.
openaire +2 more sources
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Diversification or dilution? Perspectives on generalism and subspecialization in modern psychiatry
This article explores debates in psychiatry about generalism and subspecialization, illustrating the potential benefits and issues of each in the context of service delivery and education founded on the biopsychosocial model. Recommendations are given to
Seifritz, Erich +6 more
core +1 more source
Irreversible generalism: A reply to Dickie
, 2005 Irreversible generalism, the view that reasons given for the evaluation of art are general and do not admit of exceptions, is defended from the criticisms levelled against it by George Dickie in 'Reading Sibley'.
Haydar B., Conolly O.
core +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
What Exactly (If Anything) is Wrong with Paternalism Towards Children?
Philosophical Inquiry in Education, 2017 Theoretical and practical issues concerning the justification of paternalism towards children are widely debated in a variety of philosophical contexts.
Johannes Drerup
doaj
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Turnover importance: Operationalizing beta diversity to quantify the generalism continuum
Methods in Ecology and EvolutionGeneralization is difficult to quantify, and many classifications exist. A beta diversity framework can be used to establish a numeric measure of generalist tendencies that jointly describes many important features of species interactions, namely ...
Lydia Morley +3 more
doaj +1 more source