Results 91 to 100 of about 3,776 (284)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Nature CommunicationsSpecies can directly and indirectly affect others across communities and habitats, yet the spatial scale over which such effects spread remains unclear. This uncertainty arises partly because the species traits and landscape structures allowing indirect ...
David García-Callejas +4 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Altruism and the evolution of resource generalism and specialism [PDF]
, 2012 The evolution of resource specialism and generalism has attracted widespread interest. Evolutionary drivers affecting niche differentiation and resource specialization have focused on the role of trade-offs.
Michael B. Bonsall +3 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Why the NHS needs adult generalists: A call for single certification in general internal medicine
Future Healthcare JournalAs the UK NHS faces growing challenges of the ageing population and escalating healthcare costs, we examine the role of the general internal medicine (GIM) consultant in inpatient medicine.
Elizabeth Estabrook +2 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Plant species pollinated by animals differ in the pool of visitors they attract. Some attract functionally similar animals, while others engage with a broader set of functionally distinct visitors; we term this species-level variation functional ...
Maglianesi, María A. +13 more
core +1 more source
Realizing the niche's breadth: inferring ecological process with species generalism [PDF]
, 2010 Various ecological processes affect generalist and specialist species differently. By measuring niche breadth in communities, we can infer those processes.
McChesney, Jasper
core +1 more source