Results 131 to 140 of about 3,776 (284)
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Floral offer and seasonality shape plant–pollinator networks in tropical gardens
EcosphereUrban expansion is accelerating global pressure on pollinators and their interactions with plants. Urban green spaces may nevertheless act as key refuges, provided they offer a suitable floral environment. Here, we investigated how pollinator assemblages
Nathan Cyrille +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
A Scoping Review on Generalism: core concepts for clinical training and practice
, 2019 Context: Family Medicine is being challenged to articulate the nature of Generalist work. International challenges include: measurement, quality assurance and organisation of clinical work; and shaping of clinical curricula content. Organisation of care
Abrams, Ruth +2 more
core
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Debunking Moral Generalism: New Vindications of Moral Particularism [PDF]
In this book, the idea of moral generalism, i.e. morality depends on moral principles, and its arguments are debunked. The author argues that there are no substantive true moral generalizations, and that the existence and provision of such ...
Sukristiono, Dominikus
core +2 more sources
Rural generalism: the New Zealand way [PDF]
Journal of Primary Health Care, 2018 Garry Nixon
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Generalism in species interactions is more the consequence than the cause of ecological success
Generalism in resource use is commonly considered a critical driver of population success, species distribution and extinction risk. This idea can be questioned as generalism may be a result rather than the cause of species abundance and range size.
Calatayud, Joaquín +5 more
core +1 more source