Results 91 to 100 of about 1,592,426 (314)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Retracted: The Generalization Inverse Weibull Distribution Related to X-Gamma Generator Family: Simulation and Application for Breast Cancer [PDF]
, 2023 Journal of Function Spaces
openalex +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Improving the Robustness of Neural Networks Using K-Support Norm Based Adversarial Training
IEEE Access, 2016 It is of significant importance for any classification and recognition system, which claims near or better than human performance to be immune to small perturbations in the dataset.
Sheikh Waqas Akhtar +6 more
doaj +1 more source
Robustness, Privacy, and Generalization of Adversarial Training [PDF]
, 2020 Fengxiang He +3 more
openalex +1 more source
Pediatric Nephrology, 2017 Immunosuppressive drugs for solid organ transplantation are critical dose drugs with a narrow therapeutic index. Many of the most commonly used innovator drugs are off patent and have been replicated by generic counterparts, often at substantial cost-savings to the patient.
Mara Medeiros +4 more
openaire +5 more sources
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Research on Evaluation Method of Selection for General Support Equipment Based on Competitive Test
Hangkong gongcheng jinzhan, 2018 Generalization of support equipment is the very important way to reduce the scale of support and maximize the effectiveness of support. Selection of generalization support equipment is to select qualified suppliers and models through the initial use and ...
Wang Xin, Zhang Kun
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Typification for Façade Structures Based on User Perception
ISPRS International Journal of Geo-Information, 2016 Typification is a well-established operator of map generalization. Although it is widely used in many existing research fields, less discussion has been devoted to the quality of typification.
Jie Shen +3 more
doaj +1 more source