Results 81 to 90 of about 14,674,084 (211)

Structured additive quantile regression with applications to modelling undernutrition and obesity of children [PDF]

open access: yes, 2012
Quantile regression allows to model the complete conditional distribution of a response variable - expressed by its quantiles - depending on covariates, and thereby extends classical regression models which mainly address the conditional mean of a ...
Fenske, Nora
core   +1 more source

Incorporating shape constraints in generalized additive modelling of the height-diameter relationship for Norway spruce

open access: yesForest Ecosystems, 2016
Background: Measurements of tree heights and diameters are essential in forest assessment and modelling. Tree heights are used for estimating timber volume, site index and other important variables related to forest growth and yield, succession and ...
Natalya Pya, Matthias Schmidt
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Analysis of the time to sustained progression in Multiple Sclerosis using generalised linear and additive models [PDF]

open access: yes, 2003
The course of multiple sclerosis (MS) is generally difficult to predict. This is due to the great inter-individual variability with respect to symptoms and disability status.
Hellriegel, B.   +5 more
core   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

open access: yesFEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph   +7 more
wiley   +1 more source

Structured additive regression for multicategorical space-time data: A mixed model approach [PDF]

open access: yes, 2004
In many practical situations, simple regression models suffer from the fact that the dependence of responses on covariates can not be sufficiently described by a purely parametric predictor.
Kneib, Thomas, Fahrmeir, Ludwig
core   +1 more source

Time Series Analysis of the Impact of Meteorological Conditions and Air Quality on the Number of Medical Visits for Hypertension in Haikou City, China

open access: yesAtmosphere
Meteorological conditions and air quality are important environmental factors in the occurrence and development of cardiovascular diseases (CVDs) such as hypertension.
Mingjie Zhang   +3 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

open access: yesFEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

BayesX: Analyzing Bayesian Structural Additive Regression Models

open access: yesJournal of Statistical Software, 2005
There has been much recent interest in Bayesian inference for generalized additive and related models. The increasing popularity of Bayesian methods for these and other model classes is mainly caused by the introduction of Markov chain Monte Carlo (MCMC)
Andreas Brezger   +2 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

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