Results 81 to 90 of about 66,574 (258)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Generalized Additive Models

Annual Review of Statistics and Its Application
Generalized additive models are generalized linear models in which the linear predictor includes a sum of smooth functions of covariates, where the shape of the functions is to be estimated. They have also been generalized beyond the original generalized linear model setting to distributions outside the exponential family and to situations in which ...
openaire   +2 more sources

Generalized functional additive mixed models

Electronic Journal of Statistics, 2016
We propose a comprehensive framework for additive regression models for non-Gaussian functional responses, allowing for multiple (partially) nested or crossed functional random effects with flexible correlation structures for, e.g., spatial, temporal, or longitudinal functional data as well as linear and nonlinear effects of functional and scalar ...
Scheipl, Fabian, Gertheiss, Jan, Greven, Sonja   +2 more
openaire   +4 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Effect of a mix of condense and hydrolysable tannins feed additive on lactating dairy cows’ services per conception and days open

Veterinary and Animal Science
A commercial dairy farm with two dairy units (about 3000 cows each), similar management and diets was used to evaluate the effect of a feed additive based on a mix of condense and hydrolysable tannins (ByPro®) on lactating cow services per conception and
Alejandro R Castillo, Julio A Di Rienzo, Damiano Cavallini   +2 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Unveiling the nonlinear dynamics of player performance in China’s super league as a function of age

Scientific Reports
To explore the dynamics in physical and technical performance of professional football players and changes across age groups. Match statistics were collected from 1900 games across ten seasons (2012–2021) in the Chinese Super League. Generalized additive
Jun Cao, Wei Zhang, Changjing Zhou
doaj   +1 more source

Comparing parametric and semiparametric error correction models for estimation of long run equilibrium between exports and imports

Apstract: Applied Studies in Agribusiness and Commerce, 2017
This paper introduces the semiparametric error correction model for estimation of export-import relationship as an alternative to the least squares approach.
Henry De-Graft Acquah, Lawrence Acheampong   +1 more
doaj   +1 more source

A General Framework for Prediction in Generalized Additive Models

, 2020
Smoothing techniques have become one of the most popular modelling approaches in the unidimensional and multidimensional setting. However, out-of-sample prediction in the context of smoothing models is still an open problem that can significantly widen the use of these models in many areas of knowledge.
openaire   +3 more sources