Results 71 to 80 of about 125,587 (258)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

MODELLING THE NUMBER OF CRIMES IN EAST JAVA USING A TRUNCATED SPLINE SEMIPARAMETRIC REGRESSION APPROACH

Barekeng
High crime rates can lead to unrest and financial losses for the community. East Java is one of the provinces with high crime rates, with a total of 21,046 reported crimes in 2023.
Yahya Vigo Tri Saputra, Moh. Hafiyusholeh, Hani Khaulasari, Yuniar Farida, Putroue Keumala Intan   +4 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

FDG‐PET Associations With Disease Severity and Outcomes in NMDA‐Receptor IgG Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Patients with N‐methyl‐D‐aspartate (NMDA) receptor‐immunoglobulin G (IgG) autoimmune encephalitis (NMDAR‐IgG AE) demonstrate occipital lobe hypometabolism on baseline brain fluorodeoxyglucose‐positron emission tomography (bFDG‐PET).
Jonathan K. Lee, Jeffrey Lambe, Scott Johnson, Akua Abrah, Jennifer Bullen, Jeffrey A. Cohen, Tatchaporn Ongphichetmetha, Amy Kunchok   +7 more
wiley   +1 more source

ANALISIS DATA INFLASI DI INDONESIA PASCA KENAIKAN TDL DAN BBM TAHUN 2013 MENGGUNAKAN MODEL REGRESI KERNEL

Media Statistika, 2013
The inflation data is one of the financial time series data that has a high volatility, so if the data is modeled with parametric models (AR, MA and ARIMA), sometimes occur problems because there was an assumption that cannot be satisfied.
Suparti Suparti
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Correction: Cross-cultural adaptation and psychometric validation of the Generalized Anxiety Disorder Assessment-7 for Urdu-speaking clinical populations

Healthcare in Low-resource Settings
In response to the reservations raised by the Authors of “Urdu translation and validation of GAD-7: a screening and rating tool for anxiety symptoms in primary health care” (J Pak Med Assoc 2017;67:1536-40), the Authors of the paper “Cross cultural ...
The Authors
doaj   +1 more source

Assessment of the General Response Style: A Cross-Cultural Validation

Acta de Investigación Psicológica, 2019
Surveys that use self-reports are susceptible to response styles. The assessment and validation of response styles would benefit from a brief measure that captures the general tendency of responding. Going beyond the traditional view that response styles amount to deliberate impression management or lying, we propose to assess and conducted a ...
He, Jia, van de Vijver, Fons
openaire   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source