Results 51 to 60 of about 923,744 (302)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Nil sets defined through generalized skew derivations having a Jordan-like behavior

Mathematics Open
Let R be a prime ring of characteristic different from [Formula: see text], C its extended centroid, F and G non-zero generalized skew derivations of R, associated with the same automorphism [Formula: see text] of R and [Formula: see text] a fixed ...
Francesco Ammendolia, Vincenzo De Filippis   +1 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Generalized Derivations of Prime Rings [PDF]

International Journal of Mathematics and Mathematical Sciences, 2007
LetRbe an associative prime ring,Ua Lie ideal such thatu2∈Ufor allu∈U. An additive functionF:R→Ris called a generalized derivation if there exists a derivationd:R→Rsuch thatF(xy)=F(x)y+xd(y)holds for allx,y∈R. In this paper, we prove thatd=0orU⊆Z(R)if any one of the following conditions holds: (1)d(x)∘F(y)=0, (2)[d(x),F(y)=0], (3) eitherd(x)∘F(y)=x ...
openaire   +3 more sources

Generalized Derivation Pada ?-Ring [PDF]

, 2017
Misalkan M adalah suatu ? -ring prima yang memenuhi x_y_z = x_y_z untuk setiap x; y; z 2 M , _; _ 2 ? dan U adalah suatu ideal tak nol dari M .
Purnamaadi, Dedy Zulkharnain, Dr. Noor Hidayat, M.Si   +1 more
core  

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Generalized Derivations in Rings and Their Applications to Banach Algebra

Mathematics
Let R be a prime ring, and let F denote a generalized derivation associated with a derivation d of R. Consider I as a nonzero ideal of R, and let m,n,k,l be fixed positive integers.
Amal S. Alali, Emine Koç Sögütcü, Zeliha Bedir, Nadeem ur Rehman   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source