Results 51 to 60 of about 1,650,435 (305)
Young patient with generalized lymphangiomatosis: Differentiating the differential
Indian Journal of Radiology and Imaging, 2016 AbstractWe present the case of a 19-year-old man who was extensively evaluated in multiple centres for long-standing cough, dyspnea, and hemoptysis without a definitive diagnosis. His chest radiograph at presentation showed mediastinal widening, bilateral pleural effusions, and Kerley B lines. Computed tomography of the thorax showed a confluent, fluid-
Tharani Putta +4 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
DIFFERENTIAL DIAGNOSIS OF GENERAL PARESIS [PDF]
American Journal of Psychiatry, 1914 n ...
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Network Generation with Differential Privacy
CoRR, 2020 We consider the problem of generating private synthetic versions of real-world graphs containing private information while maintaining the utility of generated graphs. Differential privacy is a gold standard for data privacy, and the introduction of the differentially private stochastic gradient descent (DP-SGD) algorithm has facilitated the training ...
Xu Zheng, Nicholas McCarthy, Jer Hayes
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Frontiers in Genetics, 2019 Restricted gene flow may lead to the loss of genetic diversity and higher genetic differentiation among populations, but the genetic consequences of megafauna extinction for plant populations still remain to be assessed.
Rosane G. Collevatti +2 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Ideals Generated by Differential Equations [PDF]
Journal of Siberian Federal University. Mathematics & Physics, 2020 We propose a new algebraic approach to study compatibility of partial differential equations. The approach uses concepts from commutative algebra, algebraic geometry and Gr¨obner bases to clarify crucial notions concerning compatibility such as passivity and reducibility.
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Nonlocal boundary value problem for a Lykov's type system of first-order
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011 In this paper we prove the unique solution of the problem with a shift to a Lykov's type system of differential equations of first order. The proof is given for different values of the generalized operators of fractional integro-differentiation included ...
Oleg A Repin, Svetlana K Kumykova
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