Results 81 to 90 of about 117,138 (265)
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Generalized Symmetries of Massless Free Fields on Minkowski Space
Symmetry, Integrability and Geometry: Methods and Applications, 2008 A complete and explicit classification of generalized, or local, symmetries of massless free fields of spin s ≥ 1/2 is carried out. Up to equivalence, these are found to consists of the conformal symmetries and their duals, new chiral symmetries of order
Stephen C. Anco, Juha Pohjanpelto
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Saigo Fractional q-Differentiation Operator Involving Generalized q-Mittag–Leffler Function
Journal of MathematicsThe purpose of this study is to obtain the images of the generalized q-analogue of Mittag–Leffler functions under the Saigo fractional q-differentiation operator, where its argument consists of a factor xζxq−μ+ξ−θ.
Mulugeta Dawud Ali, D. L. Suthar
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Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
A Minimax-Program-Based Approach for Robust Fractional Multi-Objective Optimization
MathematicsIn this paper, by making use of some advanced tools from variational analysis and generalized differentiation, we establish necessary optimality conditions for a class of robust fractional minimax programming problems.
Henan Li, Zhe Hong, Do Sang Kim
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Вестник Северо-Кавказского федерального университета, 2022 The non-stationary equation of transfer of impurity in the atmosphere is considered and for it creation of it-erative computing algorithm on the basis of operators of the generalized differentiation of the functions corre-sponding to empirical data of a ...
Roman Andreevich Riskalenko +1 more
doaj
REGIONAL DIFFERENTIATION OF TUBERCULOSIS MORTALITY IN THE RUSSIAN FEDERATION (1975-2014)
Туберкулез и болезни лёгких, 2017 Tuberculosis mortality was analyzed basing on regional differentiation in the Russian Federation in 1975-2014. Stable differences between regions when distributing this rate and its changes through time were evaluated as per two geographical regions. One
S. V. Kandrychyn
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Generating sexually differentiated songs
Current Opinion in Neurobiology, 1997 The past year has witnessed increased confusion as to the role of gonadal hormones in the development of neuroeffectors for sexually differentiated vocalizations in several species. Are sex differences in levels of circulating gonadal hormones robust enough to account for the full spectrum of male/female differences?
openaire +2 more sources
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source