Results 71 to 80 of about 628,110 (283)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Longitudinal method comparison: modeling polygenic risk for post-traumatic stress disorder over time in individuals of African and European ancestry

Frontiers in Genetics
Cross-sectional data allow the investigation of how genetics influence health at a single time point, but to understand how the genome impacts phenotype development, one must use repeated measures data.
Kristin Passero, Jennie G. Noll, Shefali Setia Verma, Claire Selin, Molly A. Hall   +4 more
doaj   +1 more source

Prevalence and associated factors of home delivery in Eastern Africa: Further analysis of data from the recent Demographic and Health Survey data

SAGE Open Medicine, 2022
Objectives: The current study aimed to determine the magnitude of home delivery and its associated factors in East Africa using data from the Demographic and Health Survey.
Lemma Demissie Regassa, Assefa Tola, Adisu Birhanu Weldesenbet, Biruk Shalmeno Tusa   +3 more
doaj   +1 more source

Local Distance-Based Generalized Linear Models using the dbstats package for R [PDF]

, 2012
This paper introduces local distance-based generalized linear models. These models extend (weighted) distance-based linear models firstly with the generalized linear model concept, then by localizing.
Boj del Val, Eva, Caballé Mestres, Adrià, Delicado, Pedro, Esteve, Anna, Fortiana Gregori, Josep, Xarxa de Referència en Economia Aplicada (XREAP)   +5 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Holistic Generalized Linear Models

Journal of Statistical Software
Holistic linear regression extends the classical best subset selection problem by adding additional constraints designed to improve the model quality.
Benjamin Schwendinger, Florian Schwendinger, Laura Vana   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Consequence of War on Diabetic Mellitus patients in Tigray region, Ethiopia: a longitudinal study

BMC Endocrine Disorders
Background Studies of the world health organization indicated that Diabetes is on the rise. The occurrence of diabetes is steadily increasing everywhere, most markedly in the world’s middle and low-income countries.
Mehari Gebre Teklezgi, Mengstu Berhe Tekle, Gebru Gebremeskel Gebrerufael, Tesfu Solomon Yeebyo   +3 more
doaj   +1 more source

Using otolith weights to estimate age for eastern sea garfish, Hyporhamphus australis

Frontiers in Fish Science
The most common method of estimating teleost ages is via sectioned otoliths. With diminishing funding and policies around cost-recovery from fishing industries, exploring cost-effective methods of estimating ages is warranted.
John Stewart, Matt K. Broadhurst, Matt K. Broadhurst, Daniel J. Tolhurst   +3 more
doaj   +1 more source