Results 71 to 80 of about 627,717 (264)

Estimation in Dirichlet random effects models

, 2010
We develop a new Gibbs sampler for a linear mixed model with a Dirichlet process random effect term, which is easily extended to a generalized linear mixed model with a probit link function.
Casella, George, Gill, Jeff, Kyung, Minjung   +2 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Holistic Generalized Linear Models

Journal of Statistical Software
Holistic linear regression extends the classical best subset selection problem by adding additional constraints designed to improve the model quality.
Benjamin Schwendinger, Florian Schwendinger, Laura Vana   +2 more
doaj   +1 more source

Prevalence and associated factors of home delivery in Eastern Africa: Further analysis of data from the recent Demographic and Health Survey data

SAGE Open Medicine, 2022
Objectives: The current study aimed to determine the magnitude of home delivery and its associated factors in East Africa using data from the Demographic and Health Survey.
Lemma Demissie Regassa, Assefa Tola, Adisu Birhanu Weldesenbet, Biruk Shalmeno Tusa   +3 more
doaj   +1 more source

Local Distance-Based Generalized Linear Models using the dbstats package for R [PDF]

, 2012
This paper introduces local distance-based generalized linear models. These models extend (weighted) distance-based linear models firstly with the generalized linear model concept, then by localizing.
Boj del Val, Eva, Caballé Mestres, Adrià, Delicado, Pedro, Esteve, Anna, Fortiana Gregori, Josep, Xarxa de Referència en Economia Aplicada (XREAP)   +5 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Consequence of War on Diabetic Mellitus patients in Tigray region, Ethiopia: a longitudinal study

BMC Endocrine Disorders
Background Studies of the world health organization indicated that Diabetes is on the rise. The occurrence of diabetes is steadily increasing everywhere, most markedly in the world’s middle and low-income countries.
Mehari Gebre Teklezgi, Mengstu Berhe Tekle, Gebru Gebremeskel Gebrerufael, Tesfu Solomon Yeebyo   +3 more
doaj   +1 more source

Using otolith weights to estimate age for eastern sea garfish, Hyporhamphus australis

Frontiers in Fish Science
The most common method of estimating teleost ages is via sectioned otoliths. With diminishing funding and policies around cost-recovery from fishing industries, exploring cost-effective methods of estimating ages is warranted.
John Stewart, Matt K. Broadhurst, Matt K. Broadhurst, Daniel J. Tolhurst   +3 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source