Results 91 to 100 of about 776,217 (345)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Local Distance-Based Generalized Linear Models using the dbstats package for R [PDF]

, 2012
This paper introduces local distance-based generalized linear models. These models extend (weighted) distance-based linear models firstly with the generalized linear model concept, then by localizing.
Boj del Val, Eva, Caballé Mestres, Adrià, Delicado, Pedro, Esteve, Anna, Fortiana Gregori, Josep, Xarxa de Referència en Economia Aplicada (XREAP)   +5 more
core  

Fence methods for mixed model selection

, 2008
Many model search strategies involve trading off model fit with model complexity in a penalized goodness of fit measure. Asymptotic properties for these types of procedures in settings like linear regression and ARMA time series have been studied, but ...
Gu, Zhonghua, Jiang, Jiming, Nguyen, Thuan, Rao, J. Sunil   +3 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Non-linear Mixed Models in a Dose Response Modelling

InPrime, 2019
Study designs in which an outcome is measured more than once from time to time result in longitudinal data. Most of the methodological works have been done in the setting of linear and generalized linear models, where some amount of linearity is retained.
Madona Yunita Wijaya
doaj   +1 more source

On the application of generalized linear mixed models for predicting path loss in LTE networks

EURASIP Journal on Advances in Signal Processing, 2023
To meet the ever-growing demand for higher data rates, accurate channel models are needed for optimal design and deployment of mobile wireless networks. This work proposes a new method for addressing path loss modeling at 800 MHz of suburban environment ...
Achraf Cohen, Yazan A. Alqudah
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Fixed or random? On the reliability of mixed‐effects models for a small number of levels in grouping variables

Ecology and Evolution, 2022
Biological data are often intrinsically hierarchical (e.g., species from different genera, plants within different mountain regions), which made mixed‐effects models a common analysis tool in ecology and evolution because they can account for the non ...
Johannes Oberpriller, Melina de Souza Leite, Maximilian Pichler   +2 more
doaj   +1 more source

Generalized linear mixed model for segregation distortion analysis [PDF]

BMC Genetics, 2011
Segregation distortion is a phenomenon that the observed genotypic frequencies of a locus fall outside the expected Mendelian segregation ratio. The main cause of segregation distortion is viability selection on linked marker loci. These viability selection loci can be mapped using genome-wide marker information.We developed a generalized linear mixed ...
Zhan, Haimao, Xu, Shizhong
openaire   +5 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source