Results 91 to 100 of about 1,034,308 (288)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Transition probabilities and measurement statistics of postselected ensembles

, 2010
It is well-known that a quantum measurement can enhance the transition probability between two quantum states. Such a measurement operates after preparation of the initial state and before postselecting for the final state.
Nielsen M. A., Tobias Fritz
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Generalized Linear Models with Covariate Measurement Error and Zero-Inflated Surrogates

Mathematics
Epidemiological studies often encounter a challenge due to exposure measurement error when estimating an exposure–disease association. A surrogate variable may be available for the true unobserved exposure variable.
Ching-Yun Wang, Jean de Dieu Tapsoba, Catherine Duggan, Anne McTiernan   +3 more
doaj   +1 more source

Variance estimation for the instrumental variables approach to measurement error in generalized linear models [PDF]

This paper derives and gives explicit formulas for a derived sandwich variance estimate. This variance estimate is appropriate for generalized linear additive measurement error models fitted using instrumental variables.
James W. Hardin, Raymond J. Carroll
core   +1 more source

Photoactivated biological processes as quantum measurements. [PDF]

, 2015
We outline a framework for describing photoactivated biological reactions as generalized quantum measurements of external fields, for which the biological system takes on the role of a quantum meter.
Imamoglu, A, Whaley, KB
core   +1 more source

Generalized Jarzynski Equality under Nonequilibrium Feedback Control

, 2010
The Jarzynski equality is generalized to situations in which nonequilibrium systems are subject to a feedback control. The new terms that arise as a consequence of the feedback describe the mutual information content obtained by measurement and the ...
H. B. Callen, J. C. Maxwell, Masahito Ueda, T. M. Cover, Takahiro Sagawa   +4 more
core   +1 more source

Partitioning General Probability Measures

The Annals of Probability, 1987
Consider n probability measures \(\mu_ 1,...,\mu_ n\) on the same measurable space. It is the aim to split the whole sample set \(\Omega\) into n measurable parts \(A_ 1,...,A_ n\) such that \(A_ j\) has nearly the same probability for each distribution. Here the author considers the case when the atoms have not too large mass.
openaire   +3 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source