Results 31 to 40 of about 29,814 (246)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Optimal Uncertainty Quantification [PDF]

, 2010
We propose a rigorous framework for Uncertainty Quantification (UQ) in which the UQ objectives and the assumptions/information set are brought to the forefront.
McKerns, M., Ortiz, M., Owhadi, H., Scovel, C., Sullivan, T. J.   +4 more
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Optimal planning of photovoltaic and distribution static compensators in medium-voltage networks via the GNDO approach

Results in Engineering
This research employs the generalized normal distribution optimizer (GNDO) to address the simultaneous integration of solar photovoltaic (PV) sources and distribution static compensators (D-STATCOMs) in medium-voltage distribution networks.
Oscar Danilo Montoya, Walter Gil-González, Luis Fernando Grisales-Noreña   +2 more
doaj   +1 more source

Riemann-Theta Boltzmann Machine

, 2020
A general Boltzmann machine with continuous visible and discrete integer valued hidden states is introduced. Under mild assumptions about the connection matrices, the probability density function of the visible units can be solved for analytically ...
Carrazza, Stefano, Haghighat, Babak, Kahlen, Jens, Krefl, Daniel   +3 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Multi-objective generalized normal distribution optimization: a novel algorithm for multi-objective problems

Cluster Computing
AbstractThis study introduces the Multi-objective Generalized Normal Distribution Optimization (MOGNDO) algorithm, an advancement of the Generalized Normal Distribution Optimization (GNDO) algorithm, now adapted for multi-objective optimization tasks. The GNDO algorithm, previously known for its effectiveness in single-objective optimization, has been ...
Nima Khodadadi, Ehsan Khodadadi, Farhad Soleimanian Gharehchopogh, El-Sayed M. EI-Kenawy, Pezhman Mardanpour, Weiguo Zhao, Farhad Soleimanian Gharehchopogh, Seyedali Mirjalili   +7 more
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Cost Optimization of AC Microgrids in Grid-Connected and Isolated Modes Using a Population-Based Genetic Algorithm for Energy Management of Distributed Wind Turbines

Mathematics
This research investigates the effectiveness of four metaheuristic algorithms, the Population-Based Genetic Algorithm, Particle Swarm Optimization, JAYA, and Generalized Normal Distribution Optimizer, for managing the energy production of wind-based ...
Luis Fernando Grisales-Noreña, Héctor Pinto Vega, Oscar Danilo Montoya, Vanessa Botero-Gómez, Daniel Sanin-Villa   +4 more
doaj   +1 more source