Results 71 to 80 of about 65,201 (238)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Understanding the relationship: Financial inclusion's influence on bank stability in emerging economies

Energy Strategy Reviews
This study examines the impact of financial inclusion on bank stability across 36 emerging economies, utilizing bank-level data from over 1,500 commercial banks spanning the period 2004 to 2023. Despite the recognized benefits of financial inclusion, its
Shaoming Han, Cheng Qian, Nawal Abdalla Adam, Norboy Karimov, Wang Zhang   +4 more
doaj   +1 more source

Machine‐Learning Decomposition Identifies a Big Two Structure in Human Personality with Distinct Neurocognitive Profiles

Advanced Science, EarlyView.
Using machine learning on a mega‐scale global dataset (n = 1,336,840) reveals a robust personality trait architecture beyond the Big Five. A Big Two model, broadly capturing social engagement and internal mentation, defines a geometric space that links personality to neurocognitive profiles.
Kaixiang Zhuang, Ji Chen, Jinfeng Han, Wei Cheng, Jiang Qiu, Jianfeng Feng, Simon Eickhoff, Deniz Vatansever   +7 more
wiley   +1 more source

Tca4rec: contrastive learning with popularity-aware asymmetric augmentation for robust sequential recommendation

Journal of Big Data
Sequential recommender systems play a pivotal role in modern recommendation scenarios by capturing users’ dynamic interests through their historical interactions.
Yanan Bai, Liji Xiao, Chongjun Xia, Kexiang Zeng, Xiaoyu Shi   +4 more
doaj   +1 more source

From Research to Returns: A Firm-Level Analysis of R&D and Productivity in the Human Health Industry

Journal of Technology Management & Innovation
In the rapidly evolving human health industry, the role of research and development (R&D) is pivotal. This study aims to investigate the relationship between R&D and labor productivity in the pharmaceutical, biotechnology, and medical device industries,
Felipe Queiroz Silva, Bernardo Pereira Cabral, Fabio Batista Mota   +2 more
doaj   +1 more source

Single‐Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re‐Sensitizer Drugs in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu, Mengqin Yuan, Yini Shang, Jiahao Chen, Fei Hou, Lihong Wang, Wei Jiang   +6 more
wiley   +1 more source

A Comparative Analysis of the Prediction of Gas Condensate Dew Point Pressure Using Advanced Machine Learning Algorithms

Fuels
Dew point pressure (DPP) emerges as a pivotal factor crucial for forecasting reservoir dynamics regarding condensate-to-gas ratio and addressing production/completion hurdles, alongside calibrating EOS models for integrated simulation.
Thitaree Lertliangchai, Birol Dindoruk, Ligang Lu, Xi Yang, Utkarsh Sinha   +4 more
doaj   +1 more source

Mass Spectrometry Imaging‐Assisted Discovery of Gallotannin Biosynthetic Genes in the Root of Paeonia suffruticosa

Advanced Science, EarlyView.
An integrated approach combining mass spectrometry imaging, transcriptomics, and phylogenetic analysis facilitated the efficient identification of genes involved in gallotannin biosynthesis in Paeonia suffruticosa. As a result, a key UGT and several SCPL acyltransferases responsible for biosynthesizing pentagalloylglucose were successfully identified ...
Yushi Liu, Wenna Duan, Weiwei Tang, Yucheng Zhao, Bin Li   +4 more
wiley   +1 more source

Unveiling the financial pathway to human development: insights from non-linear ARDL and Granger causality analysis

Humanities & Social Sciences Communications
The current study examines the relationship between financial inclusion, encompassing key indicators such as financial access, depth, efficiency, and stability, and the Human Development Index (HDI) within the BRICS economies (Brazil, Russia, India ...
Hafiz M. Sohail, Mirzat Ullah, Muhammad Shahzad Nazir, Canqing Tang   +3 more
doaj   +1 more source

Remote sensing of aboveground biomass dynamics and climatic responses in tropical lowland rainforests: Evidence from Bawangling, China

Ecological Indicators
Dynamics of tropical forests' aboveground biomass (AGB) are pivotal to the global carbon balance, yet the nonlinear and interactive mechanisms by which AGB responds to climate change in tropical lowland rainforests (TLR) remain unclear.
Yuxin Chen, Mingjiang Mao, Wenfeng Gong, Shijie Mao, Yixi Ma, Renhao Chen, Miao Wang, Xiaoxiao Zhang, Jinming Xu, Junting Jia, Peng Zhou   +10 more
doaj   +1 more source