Results 161 to 170 of about 1,609,080 (232)

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

open access: yesAdvanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo   +5 more
wiley   +1 more source

Novel <i>ITGB6</i> Mutations Causing Amelogenesis Imperfecta. [PDF]

open access: yesGenes (Basel)
Yin H   +5 more
europepmc   +1 more source

An Integrated Artificial Intelligence Framework for Nanomedicine Engineering

open access: yesAdvanced Science, EarlyView.
This review outlines a closed‐loop AI ecosystem for nanomedicine engineering. By synergizing multimodal data harmonization, objective‐driven AI architectures, and automated high‐throughput validation, this “Design‐Make‐Test‐Analyze” (DMTA) workflow transforms traditional heuristic formulation into a predictive, self‐optimizing paradigm, accelerating ...
Meichen Dong   +10 more
wiley   +1 more source

Foundation Model‐Enabled Pathology‐Informed MRI Model for Preoperative Prediction of Vessels Encapsulating Tumor Clusters in Resectable Hepatocellular Carcinoma: A Multicenter Retrospective Study

open access: yesAdvanced Science, EarlyView.
PIVOT uses pathology‐derived morphologic and vascular representations from postoperative H&E and CD34 whole‐slide images to guide model development, while clinical inference requires only preoperative multiparametric MRI. Across five centers, PIVOT enabled accurate preoperative assessment of vessels encapsulating tumor clusters, stratified patients by ...
Zhehan Shen   +12 more
wiley   +1 more source

Coral‐Biomimetic Structured Organic Electro‐Oxidations With Exceptional High‐Current Catalytic Performance

open access: yesAdvanced Science, EarlyView.
A strategy for energy‐efficient hydrogen production coupled with biomass valorization via organic electrooxidation reactions is reported. A bio‐inspired multiscale coral‐like heterostructure catalyst delivers record‐breaking OEOR performance enabled by a dual‐copper synergistic Cu+/Cu2+–Ni mechanism, establishing a universal architectural and ...
Chaoqun Pei   +17 more
wiley   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

open access: yesAdvanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy