Results 1 to 10 of about 72,244 (159)

Circuits generating secondarily generalized seizures [PDF]

Epilepsy and Behavior, 2019
Mapping the circuits underlying the generation and propagation of seizures is critically important for understanding their pathophysiology. We review evidence to suggest that circuits engaged in secondarily generalized seizures are likely to be more complex than those currently proposed.
Anastasia Brodovskaya, Jaideep Kapur
exaly   +5 more sources

The Role of Excitability and Network Structure in the Emergence of Focal and Generalized Seizures [PDF]

Frontiers in Neurology, 2020
Epileptic seizures are generally classified as either focal or generalized. It had been traditionally assumed that focal seizures imply localized brain abnormalities, whereas generalized seizures involve widespread brain pathologies.
Marinho A. Lopes, Marinho A. Lopes, Marinho A. Lopes, Marinho A. Lopes, Marinho A. Lopes, Leandro Junges, Leandro Junges, Leandro Junges, Leandro Junges, Leandro Junges, Wessel Woldman, Wessel Woldman, Wessel Woldman, Wessel Woldman, Wessel Woldman, Marc Goodfellow, Marc Goodfellow, Marc Goodfellow, John R. Terry, John R. Terry, John R. Terry, John R. Terry, John R. Terry   +22 more
doaj   +4 more sources

Recurrent generalized seizures as the prominent manifestation in a patient with CADASIL: a case report and literature review [PDF]

BMC Neurology, 2022
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited arteriopathy typically caused by mutations in the NOTCH-3 gene. Few detailed descriptions of recurrent generalized seizures in
Liuhua Pan, Yan Chen, Shanshan Zhao
doaj   +2 more sources

Cortical activation in generalized seizures. [PDF]

Epilepsia, 2019
AbstractObjectivePatients with generalized epilepsy exhibit different epileptiform events including asymptomatic interictal spikes (IS), absence seizures with spike‐wave discharges (SWDs), and myoclonic seizures (MS). Our objective was to determine the spatiotemporal patterns of cortical activation in SWDs, IS, and MS in the Gabra1+/A322D juvenile ...
Ding L, Satish S, Zhou C, Gallagher MJ.
europepmc   +4 more sources

The cerebellum contributes to generalized seizures by altering activity in the ventral posteromedial nucleus [PDF]

Communications Biology, 2023
Thalamo-cortical networks are central to seizures, yet it is unclear how these circuits initiate seizures. We test whether a facial region of the thalamus, the ventral posteromedial nucleus (VPM), is a source of generalized, convulsive motor seizures and
Jaclyn Beckinghausen, Joshua Ortiz-Guzman, Tao Lin, Benjamin Bachman, Luis E. Salazar Leon, Yu Liu, Detlef H. Heck, Benjamin R. Arenkiel, Roy V. Sillitoe   +8 more
doaj   +2 more sources

Ictal MEG-EEG Study to Localize the Onset of Generalized Seizures: To See Beyond What Meets the Eye [PDF]

Brain Sciences
Introduction: Patients with generalized epilepsy are rarely referred for advanced diagnostics like magnetoencephalography (MEG). This is due to the assumption that generalized seizures cannot be localized noninvasively.
Valentina Gumenyuk, Oleg Korzyukov, Noam Peled, Patrick Landazuri, Olga Taraschenko, Sheridan M. Parker, Darya Frank, Spriha Pavuluri   +7 more
doaj   +2 more sources

Clobazam monotherapy for focal or generalized seizures. [PDF]

Cochrane Database Syst Rev, 2018
This is an updated version of the original Cochrane Review published in Issue 10, 2014. There is a need to expand monotherapy options available to a clinician for the treatment of new focal or generalized seizures. A Cochrane systematic review for clobazam monotherapy is expected to define its place in the treatment of new-onset or untreated seizures ...
Arya R, Giridharan N, Anand V, Garg SK.
europepmc   +4 more sources

Ictal body turning and version in generalized epilepsy [PDF]

BMC Neurology
Background Ictal body turning, also known as gyratory or rotatory seizures, involves unidirectional trunk rotation of 180° or more during a seizure and is generally associated with focal epilepsies, particularly temporal and extratemporal types ...
Divya Nagabushana, Huan Huynh, Nabihah Kabir, Anna Serafini   +3 more
doaj   +2 more sources

Learning to generalize seizure forecasts [PDF]

Epilepsia, 2022
AbstractObjectiveEpilepsy is characterized by spontaneous seizures that recur at unexpected times. Nonetheless, using years‐long electroencephalographic (EEG) recordings, we previously found that patient‐reported seizures consistently occur when interictal epileptiform activity (IEA) cyclically builds up over days.
Marc G. Leguia, Vikram R. Rao, Thomas K. Tcheng, Jonas Duun‐Henriksen, Troels W. Kjær, Timothée Proix, Maxime O. Baud   +6 more
openaire   +3 more sources

Genetic epilepsy with febrile seizures plus – an overview [PDF]

Romanian Journal of Neurology, 2021
Genetic epilepsy with febrile seizures plus (GEFS+) is characterized by a group of genetic epilepsies associated predominately with an autosomal dominant pattern, but also with de novo and autosomal-recessive inheritance, these last two found in a small ...
Madalina Radu, Eugenia Roza, Daniel Mihai Teleanu, Raluca Ioana Teleanu   +3 more
doaj   +1 more source