Results 1 to 10 of about 1,856,030 (259)

Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets

Neurobiology of Disease, 2023
Generalized epilepsy affects 24 million people globally; at least 25% of cases remain medically refractory. The thalamus, with widespread connections throughout the brain, plays a critical role in generalized epilepsy.
Britta E. Lindquist, Clare Timbie, Yuliya Voskobiynyk, Jeanne T. Paz   +3 more
doaj   +2 more sources

A multicenter, matched case-control analysis comparing burden of illness among patients with tuberous sclerosis complex related epilepsy, generalized idiopathic epilepsy, and focal epilepsy in Germany. [PDF]

Neurol Res Pract
• This is the first analysis to compare QoL and direct/indirect cost burden among patients with TSC, IGE, and FE in Germany. • Generic QoL for patients with TSC was significantly lower than for patients with IGE and FE.
Lappe L, Hertzberg C, Knake S, Knuf M, von Podewils F, Willems LM, Kovac S, Zöllner JP, Sauter M, Kurlemann G, Mayer T, Bertsche A, Marquard K, Meyer S, Schäfer H, Thiels C, Zukunft B, Schubert-Bast S, Reese JP, Rosenow F, Strzelczyk A.   +20 more
europepmc   +2 more sources

A Classification Model of EEG Signals Based on RNN-LSTM for Diagnosing Focal and Generalized Epilepsy

Sensors, 2022
Epilepsy is a chronic neurological disorder caused by abnormal neuronal activity that is diagnosed visually by analyzing electroencephalography (EEG) signals.
Tahereh Najafi, Rosmina Jaafar, Rabani Remli, Wan Asyraf Wan Zaidi   +3 more
doaj   +2 more sources

Clinical characteristics, treatment patterns, and seizure control among children with focal and generalized epilepsy at a tertiary hospital in Tanzania: A cross-sectional secondary analysis. [PDF]

PLoS ONE
This study aimed to describe the clinical characteristics and treatment patterns of children with focal and generalized epilepsy and to identify factors associated with seizure control at a tertiary hospital in Tanzania.
Erneus Ernest
doaj   +2 more sources

Generalized Tonic-Clonic Seizures after Self-Limited Epilepsy with Centrotemporal Spikes: A Case Series [PDF]

Annals of Child Neurology, 2022
Purpose Patients with self-limited epilepsy with centrotemporal spikes (SLECTS) rarely experience generalized tonic-clonic seizures (GTCS) after remission, and post-remission GTCS has not been thoroughly described in earlier studies.
Hye Jin Kim, Young Joon Ko, Soo Yeon Kim, Anna Cho, Hunmin Kim, Byung Chan Lim, Hee Hwang, Jong-Hee Chae, Jieun Choi, Ki Joong Kim   +9 more
doaj   +1 more source

Contributions of Magnetoencephalography to Understanding Mechanisms of Generalized Epilepsies: Blurring the Boundary Between Focal and Generalized Epilepsies?

Frontiers in Neurology, 2022
According to the latest operational 2017 ILAE classification of epileptic seizures, the generalized epileptic seizure is still conceptualized as “originating at some point within and rapidly engaging, bilaterally distributed networks.” In contrast, the ...
Thandar Aung, Jeffrey R. Tenney, Anto I. Bagić   +2 more
doaj   +1 more source

Outpatient visit behavior in patients with epilepsy: Generalized Epilepsy is more frequently non-attendance than Focal Epilepsy.

Epilepsy & Behavior, 2023
BACKGROUND Patients with epilepsy (PWE), especially those with Idiopathic Epilepsy (GE), are at a high risk of disadvantage caused by non-adherence. It has been suggested that medical visit behavior may be a surrogate indicator of medication adherence ...
Y. Nakamura, K. Sakurai, Shuhei Ishikawa, Toru Horinouchi, Naoki Hashimoto, I. Kusumi   +5 more
semanticscholar   +1 more source

ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions

Epilepsia, 2022
In 2017, the International League Against Epilepsy (ILAE) Classification of Epilepsies described the “genetic generalized epilepsies” (GGEs), which contained the “idiopathic generalized epilepsies” (IGEs).
E. Hirsch, J. French, I. Scheffer, A. Bogacz, T. Alsaadi, M. Sperling, F. Abdulla, S. Zuberi, E. Trinka, N. Specchio, E. Somerville, Pauline Samia, K. Riney, R. Nabbout, Satish Jain, J. Wilmshurst, S. Auvin, S. Wiebe, E. Perucca, S. Moshé, P. Tinuper, E. Wirrell   +21 more
semanticscholar   +1 more source

Correlation of sleep macrostructure parameters and idiopathic epilepsies [PDF]

Arquivos de Neuro-Psiquiatria, 2002
Sleep and epilepsy share some common mechanisms. The objective of the present investigation was to study the macrostructure of sleep in patients with idiopathic epilepsies, focal and generalized, comparing these two groups to each other and to a control ...
José Roberto Santiago Barreto, Regina Maria França Fernandes, Américo Ceiki Sakamoto   +2 more
doaj   +1 more source

Cenobamate in Generalized Epilepsy and Combined Generalized and Focal Epilepsy.

Neurology Clinical Practice, 2023
Background and Objectives Cenobamate (CNB) is a United States Food and Drug Administration-approved antiseizure medication (ASM) for focal-onset seizures; however, its potential clinical effectiveness as a broad-spectrum ASM is not established. CNB has a
S. Agashe, G. Worrell, J. Britton, Katherine Noe, Anthony Ritaccio, E. Wirrell, K. Nickels, G. Cascino, D. Burkholder   +8 more
semanticscholar   +1 more source