Results 11 to 20 of about 1,856,030 (259)

A natural marmoset model of genetic generalized epilepsy

Molecular Brain, 2022
Epilepsy has been extensively studied as a common neurological disease. Efforts have been made on rodent and other animal models to reveal the pathogenic mechanisms of epilepsy and develop new drugs for treatment.
Xiangyu Yang, Zhitang Chen, Ziying Wang, Guang He, Zhiqiang Li, Yongyong Shi, Neng Gong, Binglei Zhao, Yifang Kuang, Eiki Takahashi, Weidong Li   +10 more
doaj   +1 more source

Idiopathic Generalized Epilepsy

Neurology, 2023
The idiopathic generalized epilepsies (IGE) make up a fifth of all epilepsies, but
O. Devinsky, Christopher Elder, Shobi Sivathamboo, I. Scheffer, M. Koepp   +4 more
semanticscholar   +1 more source

Maladaptive myelination promotes generalized epilepsy progression

Nature Neuroscience, 2022
Activity-dependent myelination can fine-tune neural network dynamics. Conversely, aberrant neuronal activity, as occurs in disorders of recurrent seizures (epilepsy), could promote maladaptive myelination, contributing to pathogenesis.
J. Knowles, Haojun Xu, C. Soane, Ankita Batra, Tristan Saucedo, Eleanor Frost, L. Tam, Danielle A. Fraga, Lijun Ni, Katlin Villar, Sydney Talmi, J. Huguenard, Michelle Monje   +12 more
semanticscholar   +1 more source

Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression

Nature Communications, 2022
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms and macroscale connectomics remain unclear.
S. Larivière, J. Royer, Raúl Rodríguez-Cruces, C. Paquola, M. Caligiuri, A. Gambardella, L. Concha, S. Keller, F. Cendes, Clarissa Yasuda, L. Bonilha, E. Gleichgerrcht, N. Focke, M. Domin, Felix von Podewills, S. Langner, C. Rummel, R. Wiest, Pascal Martin, R. Kotikalapudi, T. O'Brien, B. Sinclair, L. Vivash, P. Desmond, Elaine H. Lui, A. Vaudano, S. Meletti, M. Tondelli, S. Alhusaini, C. Doherty, G. Cavalleri, N. Delanty, R. Kälviäinen, G. Jackson, Magdalena A Kowalczyk, M. Mascalchi, M. Semmelroch, R. Thomas, H. Soltanian-Zadeh, E. Davoodi-bojd, Junsong Zhang, G. Winston, Aoife Griffin, Aditi Singh, Vijay K. Tiwari, Barbara A. K. Kreilkamp, M. Lenge, R. Guerrini, K. Hamandi, S. Foley, T. Rüber, B. Weber, C. Depondt, Julie Absil, Sarah J. A. Carr, E. Abela, M. Richardson, O. Devinsky, M. Severino, P. Striano, D. Tortora, E. Kaestner, S. Hatton, S. Vos, L. Caciagli, J. Duncan, C. Whelan, P. Thompson, S. Sisodiya, A. Bernasconi, A. Labate, C. McDonald, N. Bernasconi, B. Bernhardt   +73 more
semanticscholar   +1 more source

Febrile Seizures in Idiopathic/Genetic Generalized and Self-Limited Focal Epilepsies

Archives of Epilepsy, 2021
Objectives:Febrile seizure (FS) is the most common form of childhood seizures. Furthermore, idiopathic/generalized and focal/self-limited epilepsies present at the similar age-range. They usually have a favorable outcome.
Feray BÖLÜKBAŞI TÜMAY, Mecbure NALBANTOĞLU, Rahşan İNAN, Figen YAVLAL, Veysi DEMİRBİLEK   +4 more
doaj   +1 more source

Sleep quality and architecture in Idiopathic generalized epilepsy: A systematic review and meta-analysis.

Sleep Medicine Reviews, 2022
Idiopathic generalized epilepsies are a group of sleep related epilepsy syndromes with sleep deprivation as a strong trigger for seizures and increased spike-wave activity during sleep and transition to sleep.
Julia Lehner, Julia Frueh, A. Datta
semanticscholar   +1 more source

Transcutaneous Auricular Vagus Nerve Stimulation Differently Modifies Functional Brain Networks of Subjects With Different Epilepsy Types

Frontiers in Human Neuroscience, 2022
Epilepsy types differ by pathophysiology and prognosis. Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive treatment option in epilepsy. Nevertheless, its mode of action and impact on different types of epilepsy are still unknown.
Randi von Wrede, Thorsten Rings, Thorsten Rings, Timo Bröhl, Timo Bröhl, Jan Pukropski, Sophia Schach, Christoph Helmstaedter, Klaus Lehnertz, Klaus Lehnertz, Klaus Lehnertz   +10 more
doaj   +1 more source

Network Substrates of Centromedian Nucleus Deep Brain Stimulation in Generalized Pharmacoresistant Epilepsy

Neurotherapeutics, 2021
Deep brain stimulation (DBS), specifically thalamic DBS, has achieved promising results to reduce seizure severity and frequency in pharmacoresistant epilepsies, thereby establishing it for clinical use.
Cristina V Torres Díaz, G. González-Escamilla, D. Ciolac, Marta Navas García, P. Pulido Rivas, R. Sola, Antonio Barbosa, J. Pastor, L. Vega-Zelaya, Sergiu Groppa   +9 more
semanticscholar   +1 more source

Similar Profile and Magnitude of Cognitive Impairments in Focal and Generalized Epilepsy: A Pilot Study

Frontiers in Neurology, 2022
Introduction: Cognitive impairments in epilepsy are not well-understood. In addition, long-term emotional, interpersonal, and social consequences of the underlying disturbances are important to evaluate.Purpose: To compare cognitive function including ...
Helena Gauffin, Helena Gauffin, Anne-Marie Landtblom, Anne-Marie Landtblom, Anne-Marie Landtblom, Anne-Marie Landtblom, Anne-Marie Landtblom, Patrick Vigren, Patrick Vigren, Andreas Frick, Maria Engström, Maria Engström, Anita McAllister, Anita McAllister, Thomas Karlsson, Thomas Karlsson   +15 more
doaj   +1 more source

Atypical juvenile myoclonic epilepsy with structural brain abnormalities and cognitive impairment: A case report [PDF]

Romanian Journal of Neurology, 2023
Juvenile myoclonic epilepsy (JME) is an idiopathic generalized epilepsy affecting 5–10% of epilepsy patients. Its exact cause remains unknown, but recent studies indicate frontal region involvement.
Putri Permata Sari, Prastiya Indra Gunawan, Riza Noviandi, Sunny Mariana Samosir   +3 more
doaj   +1 more source