ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
A novel shifted Vieta-Lucas spectral collocation approach for multidimensional generalized Benjamin-Bona-Mahony-Burgers equations. [PDF]
Sci RepHafez RM +4 more
europepmc +1 more source
Solving Medium to Large Sized Euclidean Generalized Minimum Spanning Tree Problems [PDF]
The generalized minimum spanning tree problem is a generalization of the minimum spanning tree problem. This network design problems finds several practical applications, especially when one considers the design of a large-capacity backbone network ...
Ghosh, Diptesh
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen +7 more
wiley +1 more source
A hybrid analytical-machine learning framework for data-driven modeling of soliton solutions in the complex Ginzburg-Landau equation. [PDF]
Sci ProgMuhammad J, Tedjani AH, Yao F, Younas U.
europepmc +1 more source
The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp +4 more
wiley +1 more source
Generalized Eigenvalue Problem in Subspace-Based Excited-State Methods for Quantum Computers. [PDF]
J Chem Theory ComputKwao PF +3 more
europepmc +1 more source
A Probabilistic Tabu Search Algorithm for the Generalized Minimum Spanning Tree Problem [PDF]
In this paper we present a probabilistic tabu search algorithm for the generalized minimum spanning tree problem. The basic idea behind the algorithm is to use preprocessing operations to arrive at a probability value for each vertex which roughly ...
Ghosh, Diptesh
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao +6 more
wiley +1 more source
Decomposable and Essentially Univariate Mass-Action Systems: Extensions of the Deficiency One Theorem. [PDF]
J Nonlinear SciDeshpande A, Müller S.
europepmc +1 more source