Results 41 to 50 of about 1,076,084 (287)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Topology change and context dependence [PDF]
, 1999 The nonclassical features of quantum mechanics are reproduced using models constructed with a classical theory-general relativity. The inability to define complete initial data consistently and independently of future measurements, nonlocality, and the ...
Hadley, Mark J.
core +1 more source
Applied General Topology, 2003 Recently it was shown that, in a metric space, the upper Wijsman convergence can be topologized with the introduction of a new far-miss topology. The resulting Wijsman topology is a mixture of the ball topology and the proximal ball topology.
Giuseppe Di Maio +2 more
doaj +1 more source
Generalized Circuit Topology of Folded Linear Chains
iScience, 2020 Summary: A wide range of physical systems can be formally mapped to a linear chain of sorted objects. Upon introduction of intrachain interactions, such a chain can “fold” to elaborate topological structures, analogous to folded linear polymer systems ...
Anatoly Golovnev, Alireza Mashaghi
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Generative Topological Networks
CoRRGenerative methods have recently seen significant improvements by generating in a lower-dimensional latent representation of the data. However, many of the generative methods applied in the latent space remain complex and difficult to train. Further, it is not entirely clear why transitioning to a lower-dimensional latent space can improve generative ...
Alona Levy-Jurgenson, Zohar Yakhini
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao +6 more
wiley +1 more source
Weakly and Nearly Countably Compactness in Generalized Topology
Axioms, 2023 We define the notions of weakly μ-countably compactness and nearly μ-countably compactness denoted by Wμ-CC and Nμ-CC as generalizations of μ-compact spaces in the sense of Csaśzaŕ generalized topological spaces.
Zuhier Altawallbeh +3 more
doaj +1 more source