Results 31 to 40 of about 2,056,373 (227)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

FOURIER-BESSEL LIPSCHITZ FUNCTIONS IN THE SPACE LP [PDF]

, 2016
In this paper, we obtain an analog of Youniss Theorem 5.2 in [5] forthe generalized Fourier-Bessel transform on the real line for functions satisfying the Fourier-Bessel Lipschitz condition in the space ...
Daher, Radouan, El Hamma, Mohamed, El Ouadih, Salah   +2 more
core  

Generalized Nevanlinna Functions: Operator Representations, Asymptotic Behavior

, 2015
This article gives an introduction and short overview on generalized Nevanlinna functions, with special focus on asymptotic behavior and its relation to the operator representation. 
Annemarie Luger, Luger, Annemarie,
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

The induced generalized OWA operator [PDF]

, 2009
We present the induced generalized ordered weighted averaging (IGOWA) operator. It is a new aggregation operator that generalizes the OWA operator, including the main characteristics of both the generalized OWA and the induced OWA operator. This operator
Gil-Lafuente, Anna M., Merigo Lindahl, Jose, Merigó, José M.   +2 more
core   +3 more sources

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Some Remarks Concerning the Jacobi-Dunkl Transform in the Space Lp(R,Aα,β(t)dt)

International Journal of Analysis and Applications, 2015
In this paper, using a generalized Jacobi-Dunkl translation operator, we obtain a generalization of Titchmarsh’s theorem for the Dunkl transform for functions satisfying the (φ,p)-Lipschitz Jacobi-Dunkl condition in the  space Lp(R,Aα,β(t)dt),α ≥ β ≥−1/2,
R. Daher, S. El Ouadih, A. Belkhadir
doaj   +2 more sources

Indefinite Hamiltonian systems whose Titchmarsh–Weyl coefficients have no finite generalized poles of non-positive type [PDF]

, 2013
The two-dimensional Hamiltonian system (*)  y'(x)=zJH(x)y(x),  x∈(a,b), where the Hamiltonian H takes non-negative 2x2-matrices as values, and $J:= \begin{pmatrix} 0 & -1 \\ 1 & 0 \end{pmatrix}$, has attracted a lot of interest over the past decades ...
Harald Woracek, Matthias Langer, Langer, Matthias, Woracek, Harald   +3 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source