Results 41 to 50 of about 1,968,597 (257)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

High order Riesz transforms and mean value formula for generalized translate operator [PDF]

Journal of Inequalities and Applications, 2014
In this paper, the mean value formula depends on the Bessel generalized shift operator corresponding to the solutions of the boundary value problem related to the Bessel operator are studied. In addition to, Riesz Bessel transforms related to the Bessel operators are studied. Since Bessel generalized shift operator is translation operator corresponding
Ekincioglu I., Sayan H.H., Keskin C.
openaire   +5 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Some Remarks Concerning the Jacobi-Dunkl Transform in the Space Lp(R,Aα,β(t)dt)

International Journal of Analysis and Applications, 2015
In this paper, using a generalized Jacobi-Dunkl translation operator, we obtain a generalization of Titchmarsh’s theorem for the Dunkl transform for functions satisfying the (φ,p)-Lipschitz Jacobi-Dunkl condition in the  space Lp(R,Aα,β(t)dt),α ≥ β ≥−1/2,
R. Daher, S. El Ouadih, A. Belkhadir
doaj   +2 more sources

WITHDRAWN: Generalized translation operator and Heat equation for the generalized canonical Fourier Bessel transform

, 2023
Abstract Note: Please see pdf for full abstract with equations. The aim of this paper is to introduce a translation operator associated to the generalized linear canonical Fourier Bessel transform F m α,n
Zakaria SADIK, Abdellatif AKHLIDJ
openaire   +2 more sources

A Fractional - spread defuzzification framework for n-tuple fuzzy numbers with application to nonlinear optimization [PDF]

EPJ Web of Conferences
When decision variables exhibit asymmetric and multiscale uncertainty, ranking fuzzy numbers continues to be a major difficulty in nonlinear optimization.
Sagayaraj A C Charles, Sheela A C Santha
doaj   +1 more source

On the adjoint of a symmetric operator [PDF]

, 2007
In general it is a non-trivial task to determine the adjoint S* of an unbounded symmetric operator S in a Hilbert or Krein space. We propose a method to specify S* explicitly which makes use of two boundary mappings that satisfy an abstract Green's ...
Meda S., Nelly Villamizar, CATALISANO, MARIA VIRGINIA, E. CARLINI, Matilde Lalín, Saito, Morihiko, Mauceri G., Fernandes de Oliveira, GM, Yuzvinsky, Sergey, Nero Budur, Vallarino, Maria, PICCIONE, P., Matthias Langer, Behrndt, Jussi, Frank Sottile (7161257), Morihiko Saito, Hynek Kovařík, PEREIRA, Antonio L., M. V. CATALISANO, Budur, Nero, Langer, Matthias, Elisa Postinghel, Stefano Meda, Lotoreichik, Vladimir, JAVALOYES, M. A., Catalisano M.V, Carlini, Enrico, Mauceri, G., Giancarlo Mauceri, Sergey Yuzvinsky, CATALISANO M. V., PEREIRA, Marcone C., Jussi Behrndt, MAUCERI, GIANCARLO, Wadim Zudilin, Veys, Willem, S. Meda, Detchat Samart, M. Vallarino, Catalisano, M.V., G. Mauceri, Frank Sottile, Elisa Postinghel (2887796), BILIOTTI, L., Meda, S., Kovarik, Hynek, Maria Vallarino, Nelly Villamizar (7161260)   +47 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Simultaneous symmetry breaking in spontaneous Floquet states: temporal Floquet-Nambu-Goldstone modes, Floquet thermodynamics, and the time operator [PDF]

Quantum
We study simultaneous symmetry breaking in spontaneous Floquet states, focusing on the specific case of an atomic condensate. We first describe the quantization of the Nambu-Goldstone (NG) modes for a stationary state simultaneously breaking several ...
Juan Ramón Muñoz de Nova, Fernando Sols   +1 more
doaj   +1 more source