Results 41 to 50 of about 764,748 (296)
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Generating Function for Projected Entangled-Pair States
PRX QuantumDiagrammatic summation is a common bottleneck in modern applications of projected entangled-pair states, especially in computing low-energy excitations of a two-dimensional quantum many-body system.
Wei-Lin Tu +5 more
doaj +1 more source
On the Distribution of Generating Functions [PDF]
Bulletin of the London Mathematical Society, 1998 The generating function \(f_P(\alpha)\) associated with the \(k\)th powers is defined by \[ f_P(\alpha)= \sum_{1\leq n\leq P} \exp(i2\pi\alpha n^k). \] For \(\alpha\in (0,1]\), let \(f(\alpha)= P^{-1/2}|f_P(\alpha)|\). It has been conjectured that \[ \int_0^1 f(\alpha)^s d\alpha\sim \Gamma (\tfrac s2+1).
Vaughan, RC, Wooley, TD
openaire +3 more sources
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Asymptotic results for the first and second moments and numerical computations in discrete-time bulk-renewal process [PDF]
Yugoslav Journal of Operations Research, 2019 This paper introduces a simplified solution to determine the asymptotic results for the renewal density. It also offers the asymptotic results for the first and second moments of the number of renewals for the discrete-time bulk-renewal process.
Kim James J. +2 more
doaj +1 more source
On Generalized Stieltjes Functions [PDF]
Constructive Approximation, 2018 17 ...
Koumandos, Stamatis +3 more
openaire +6 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source