Results 61 to 70 of about 493,121 (267)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Perimeter of a palindromic composition [PDF]

open access: yesDiscrete Mathematics Letters, 2023
Aubrey Blecher, Toufik Mansour
doaj   +1 more source

Generalized Gudermannian function

open access: yesIssues of Analysis, 2018
Summary: Wilker and Huygens-type inequalities involving generalized Gudermannian function and its inverse function are established. These results are obtained with the aid of the \(p\)-version of the Schwab-Borchardt mean. Generalized one-parameter trigonometric and hyperbolic functions play a crucial role in this paper.
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Determinants of some Hessenberg matrices with generating functions

open access: yesSpecial Matrices, 2022
In this paper, we derive some relationships between the determinants of some special lower Hessenberg matrices whose entries are the terms of certain sequences and the generating functions of these sequences.
Leerawat Utsanee, Daowsud Katthaleeya
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Some New Generating Functions for q-Hahn Polynomials

open access: yesJournal of Applied Mathematics, 2014
We obtain some new generating functions for q-Hahn polynomials and give their proofs based on the homogeneous q-difference operator.
Yun Zhou, Qiu-Ming Luo
doaj   +1 more source

Generating Functions for Bessel Functions [PDF]

open access: yesCanadian Journal of Mathematics, 1959
On replacing the parameter n in Bessel's differential equation1.1by the operator y(∂/∂y), the partial differential equation Lu = 0 is constructed, where1.2This operator annuls u(x, y) = v(x)yn if, and only if, v(x) satisfies (1.1) and hence is a cylindrical function of order n.
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

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