Results 91 to 100 of about 616,857 (302)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

An auction framework to integrate dynamic transmission expansion planning and pay-as-bid wind connection auctions. ESRI WP523. January 2016 [PDF]

, 2016
Efficient renewables deployment requires the minimisation of both internal generation costs and external transmission expansion planning (TEP) costs.
Devine, Mel T., Farrell, Niall, Soroudi, Alireza   +2 more
core   +1 more source

Goal-Oriented Graph Generation for Transmission Expansion Planning

Engineering Applications of Artificial Intelligence
The electrification strategies that are being designed to meet sustainability objectives and rising energy demands pose significant challenges for power systems worldwide and require Transmission Expansion Planning (TEP). This study adopts a risk-informed approach to TEP, formulated as a multi-objective optimization problem that concurrently minimizes ...
Anna Varbella, Blazhe Gjorgiev, Federico Sartore, Enrico Zio, Giovanni Sansavini   +4 more
openaire   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

N-K Constrained Composite Generation and Transmission Expansion Planning With Interval Load

IEEE Access, 2017
The uncertainties of the predicted load demand and N-K contingencies are very significant aspects to composite generation and transmission expansion planning (CGTEP).
Shaoyun Hong, Haozhong Cheng, Pingliang Zeng   +2 more
doaj   +1 more source

A model for the determination of optimal electric generating system expansion patterns [PDF]

, 1973
Essentially constitutes a M.S. thesis in the Sloan School of Management and the Dept. of Civil EngineeringLong range electric generating capacity expansion planning requires consideration of a diverse range of issues including economic and financial ...
Farrar, Dennis Lloyd, Woodruff, Frederick   +1 more
core  

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Optimal development of electricity generation mix considering fossil fuel phase-out and strategic multi-area interconnection. ESRI WP616, February 2019 [PDF]

, 2019
Increased renewable generation worldwide is posing new challenges for power system planners. The location, as well as the level and operation, of each generation resource is increasingly important.
Bertsch, Valentin, Fitiwi, Desta Z., Lynch, Muireann   +2 more
core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source