Results 161 to 170 of about 1,314,573 (305)

Fine-Tuned Large Language Models for Generating Multiple-Choice Questions in Anesthesiology: Psychometric Comparison With Faculty-Written Items. [PDF]

JMIR Form Res
Hölzing CR, Meynhardt C, Meybohm P, König S, Kranke P.   +4 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Comparative evaluation of temperature generation during laser lithotripsy: thulium fiber laser, pulsed thulium: YAG, and holmium: YAG with pulse modulation in an ex vivo porcine kidney model. [PDF]

Urolithiasis
Gao B, Sheetz T, Ali A, Griffiths L, Sims H, Gao H, Huang TR, Hadidi Y, Saadat S, Finegan J, Nguyen V, Nackeeran S, Bechis SK, Patel RM.   +13 more
europepmc   +1 more source

Generation Mean Analysis and Molecular Markers for Salinity Tolerance during Wheat Germination and Seedling Stage [PDF]

, 2020
Mohamed H. Mahmoud, Hamdy M. El-Aref, A.S. Taghian, B. Abd El-Fatah, Mohamed Abou-Ellail   +4 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Multigenerational effects of uranium exposure reveal stronger testicular dysregulation in the second generation. [PDF]

Curr Res Toxicol
Legendre A, Gloaguen C, Kereselidze D, Saci N, Murat El Houdigui S, Froment P, Elie C, Defoort C, Lestaevel P, Benadjaoud MA, Souidi M, Grison S.   +11 more
europepmc   +1 more source

Generation mean analysis studies in chickpea (Cicer arietinum L.) genotypes [PDF]

AR Patil, DV Kusalkar, VP Gulwane, NS Kute   +3 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Chemically Derived Hepatic Progenitors Are Reprogrammed through Autophagy Suppression by A83-01. [PDF]

Int J Stem Cells
Kim H, Kim S, Salas-Silva S, Choi D, Shin JH.   +4 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source