Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A longitudinal analysis of second-generation disadvantaged immigrants [PDF]
In this paper we consider the relative academic achievement in primary school of second generation immigrant children in the UK. We use data for a cohort born in 1970 and find that children born to South Asian or Afro-Caribbean parents have significantly
Muriel Meunier +3 more
core
Analysis of yield and its components in black gram through generation mean analysis
Understanding the gene action governing yield and its component traits is crucial for developing an effective breeding strategy. In the present study, generation mean analysis was employed to unravel the genetic architecture of yield and its component ...
Ponnusamy, J +5 more
core +1 more source
Artificial intelligence applications in automated dental report generation - a scoping review. [PDF]
Front Oral HealthYon M, Ng E, Bornstein MM.
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
From means to meaningful: undertaking cluster analysis to develop health literacy profiles of people in Australian prisons. [PDF]
PLoS OneGill SW +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Automatic Generation Of High Quality DSM Based On IRS-P5 CARTOSAT-1 Stereo Data
, 2010 IRS-P5 Cartosat-1 high resolution stereo satellite imagery is well suited for the creation of digital surface models (DSM). A system for highly automated and operational DSM and orthoimage generation based on IRS-P5 Cartosat-1 imagery is presented, with ...
Carl, Sebastian +4 more
core
A Cultural Values Model of <i>Pakikipag-ugnayan:</i> Examining <i>Hiya, Pakikisama,</i> and <i>Pakikipag-ugnayan</i> among Filipino Generation Z Nurses. [PDF]
Acta Med PhilippAvila AB +7 more
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source