Results 111 to 120 of about 80,691 (309)
Temporal and generational changes in depression among young American adults
Journal of Affective Disorders ReportsThe prevalence of depression among young American adults has risen significantly over the past two decades, but the mechanisms that underlie the population-level changes in depressive symptoms severity remain unclear.
Ashley W. Kranjac +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Legal socialization effects on democratization [PDF]
, 1997 As is the case with all our joint publications, this article represents a genuine research collaboration between the authors, with equal contributions. Therefore, neither is first or second author. This article uses data from a collaborative project that
Cohn, Ellen S, White, Susan O
core +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
DECOMPOSING RED MEAT, POULTRY, AND FISH EXPENDITURES INTO AGE, TIME, AND COHORT EFFECTS [PDF]
This paper decomposes red meat, poultry, and fish consumption into cohort, age, and time effects. Younger cohorts spend less in real terms than older cohorts. These findings suggest strong implications for future consumption and nutrient intakes in the U.
Blisard, Noel, Harris, James Michael
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A comparative study of forecasting container throughput through time series analysis [PDF]
, 2017 This paper shows different techniques used in the operational research to encounter with forecasting the total container throughput handling. Each techniques approached has its objective and constraints regarding to the research problem.
Ismail, Zuhaimy +2 more
core
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Determining the Causes of the Rising South African Unemployment Rate: An Age, Period and Generational Analysis [PDF]
This paper takes advantage of the wealth of cross-sectional household surveys conducted after South Africa’s political transition, in order to gain insights into the causes of the acceleration in the already high unemployment rate.
Dieter von Fintel, Rulof Burger
core +3 more sources
Cohort Profile: Generation Victoria (GenV)
Key Features Generation Victoria (GenV) is a whole-of-state research platform established to improve child and adult health, development and wellbeing through discovery and interventional research.
Elizabeth K. Hughes +15 more
openaire +1 more source