Results 121 to 130 of about 80,691 (309)
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Values and religion in rural America: attitudes toward abortion and same-sex relations [PDF]
, 2006 The rural vote is critical, but how do rural voters\u27 views on issues such as abortion, same-sex marriage, and religion influence elections? This brief compares rural and urban views on these divisive issues and examines how much rural opinions vary ...
Dillon, Michele, Savage, Sarah
core +1 more source
Stratified case-cohort analysis of general cohort sampling designs
, 2006 We first point out that variance estimates for regression coefficients in exposure stratified case-cohort studies (Borgan et al., 2000) can easily be obtained from influence terms routinely calculated in standard software for Cox regression. We also place the estimators proposed by Chen (2001) for a general class of cohort sampling designs within the ...
Samuelsen, Sven Ove +2 more
openaire +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
The young and the hawkish: Generational differences in conflict attitudes in Israel
Research & PoliticsHow do generational patterns affect public opinion in prolonged conflicts? While considerable research has addressed the effects of conflicts on children and adolescents, understanding the broader generational divides in public attitudes towards conflict
Liran Harsgor
doaj +1 more source
Challenges in moving from macro to micro: Population and family structures in ageing societies [PDF]
Assumptions are often made about how population ageing on the macro level has altered generational structures of families at the micro level. The purpose of this paper is to increase the awareness of challenges and potential pitfalls in bridging the two ...
Gunhild Hagestad, Katharina Herlofson
core
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
A Comparison of National Saving Rates in the UK, US and Italy [PDF]
We develop the approach of Gokhale et al. (1996), based on the life-cycle model of savings, to decompose the di?erences in the national saving rates between the UK, US and Italy.
James Sefton, Tatiana Kirsanova
core