Results 221 to 230 of about 80,691 (309)

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Dopamine, Distraction, and Disruption: Perspectives on How Technology and Generation Z Are Reshaping Medical Education.

JMIR Med Educ
Andrade BB, Araújo Pereira M, Avena K.
europepmc   +1 more source

COVID-19 outcomes by immigrant generation in Sweden: a national cohort population-based study. [PDF]

Eur J Public Health
Cederström A, Rostila M, Juárez SP.
europepmc   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Intergenerational healthcare ethics: considering conceptualizations of generations and their collective and temporal dimensions. [PDF]

Med Health Care Philos
Ellerich-Groppe N, Bozzaro C, Koesling D, Rehmann-Sutter C, Schicktanz S, Schweda M.   +5 more
europepmc   +1 more source

A model of the intergenerational transmission of educational success [PDF]

, 2004
Duckworth, Kathryn, Feinstein, Leon, Sabates, Ricardo   +2 more
core   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

Long-Term Cancer Incidence Trends in Korea (2001-2020): An Age-Period-Cohort and Joinpoint Analysis with a Focus on Younger Cohorts. [PDF]

Medicina (Kaunas)
Lee H, Kim M, Song G, Joung JY, Seo H, Yoon JH, Chung J.   +6 more
europepmc   +1 more source

Intelligent Stain‐Free Histology on Structural Colorimetric Nanocavities

Advanced Science, EarlyView.
Chen and Gan et al. introduce a label‐free imaging platform using inexpensive Nanocavity‐on‐Silicon (NOS) slides. These slides transform subtle tissue variations into vivid structural colors, enabling high‐contrast histological imaging under a regular optical microscope. This stain‐free approach reveals morphological details comparable to traditional H&
Qizhe Chen, Yifei Ren, Lijie Hu, Yanyan Li, Wenyue Liang, Jin Wang, Han Gao, Xinhai Wang, Jiajun Li, Qiutao He, Yingfeng Zhu, Haifeng Hu, Qiwen Zhan, Imed Gallouzi, Jasmeen Merzaban, Di Wang, Zunguo Du, Xiaodong Gu, Qiaoqiang Gan   +18 more
wiley   +1 more source

Generational effects in Down syndrome: Enriched environment enhances functionality without reducing Alzheimer's disease risk. [PDF]

Alzheimers Dement
Vaqué-Alcázar L, Videla L, Benejam B, Del Hoyo Soriano L, Barroeta I, Fernandez S, Rodríguez-Baz Í, Arriola-Infante JE, Arranz J, Maure Blesa L, Sanjuan-Hernández A, Morcillo-Nieto AO, Bejanin A, Arenaza-Urquijo EM, Lleó A, Bartrés-Faz D, Carmona-Iragui M, Fortea J.   +17 more
europepmc   +1 more source