Results 241 to 250 of about 80,691 (309)

Chronic early life stress alters the microbial and transcriptional profile of the zebrafish gut. [PDF]

Sci Rep
Norloff E, Coker K, Tusneem S, Dixon CT, Zhu K, Graves CL.   +5 more
europepmc   +1 more source

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Reproductive Shifts and Ovarian Cancer Risk in Women Aged 40 Years or Older. [PDF]

JAMA Netw Open
Kim JH, Hwang IS, Lee SJ, Kim CJ, Lee SJ, Han K.   +5 more
europepmc   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Age-period-cohort effect on motor neuron disease mortality in the United States, 2001-2020. [PDF]

Front Neurol
Raymond J, Larson T, Nair T, Kaufman J, Horton DK, Weisskopf M, Mohidul S, Mehta P.   +7 more
europepmc   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Generational trends in reproductive factors among women in the US: implications for breast cancer incidence. [PDF]

Breast Cancer Res
Yang L, Toriola AT.
europepmc   +1 more source

Quality of life of generations X, Y, and Z in Saudi Arabia: a cross-sectional comparative analysis. [PDF]

BMC Public Health
Algamdi MM.
europepmc   +1 more source

Behavioral dataset for Long-Evans and its schizophrenia-like substrain through several generations. [PDF]

Sci Data
Kőrösi G, Czimbalmos O, Kekesi G, Horvath G.   +3 more
europepmc   +1 more source