Results 111 to 120 of about 819,389 (297)
BMC Public HealthBackground Diabetes prevalence has increased over the past few decades, and the shift of the burden of diabetes from the older population to the younger population has increased the exposure of longer durations in a morbid state.
Palak Sharma +4 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Indeterminacy, bifurcations and chaos in an overlapping generations model with negative environmental externalities [PDF]
We analyze an overlapping generations model where agent’s welfare depends on three goods: leisure, environmental quality and consumption of a private good.
Antoci, Angelo, Sodini, Mauro
core
Changing generations: Findings from new research on intergenerational relations in Ireland [PDF]
, 2013 This report presents key findings from the Changing Generations study – a collaborative research project undertaken between 2011 and 2013 by the Social Policy and Ageing Research Centre (SPARC), Trinity College Dublin, and the Irish Centre for Social
Carney, Gemma +3 more
core
Experimental GerontologyObjectives: As populations age globally, understanding the dynamics that influence the well-being of older individuals become increasingly crucial.
Amiya Saha +3 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Transfers and reciprocity in overlapping generations experiments [PDF]
We experimentally investigate the development of voluntary transfers in an overlapping generations environment. By varying the information conditions of the game, we study whether the development of transfers is related to the possibility of future ...
Potters, J.J.M. +3 more
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source