Results 121 to 130 of about 819,389 (297)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The contextual database of the Generations and Gender Program: overview, conceptual framework and the link to the Generations and Gender Survey [PDF]
This paper follows two aims. First it intends to give an overview of the contextual database of the Generations and Gender Program and how it is linked to the Generations and Gender Survey.
Martin Spielauer
core
Generations In Family Business: A Multi-Field Review And Future Research Agenda
, 2020 The concept of generations has become increasingly important in the social sciences to explain diverse phenomena affecting organizations as succession, identity construction, mobility and technological change.
Paola Rovelli +3 more
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
How to Protect Future Generations Using Tax Base Restrictions [PDF]
This paper studies constitutional restrictions on the tax base that protect future generations from expropriation and improve the optimality of investment in Intergenerational Public Goods (IPGs). The choice of the tax base matters because it affects how
Antonio Rangel
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The taxation of savings in overlapping generations economies with unbacked risky assets [PDF]
This paper establishes, in the context of the Diamond (1965) overlapping generations economy with production, that the risk that savings in unbacked assets (like fiat money or public debt) become worthless implies that, not only the first-best steady ...
Julio Davila
core +2 more sources
Linkages of quality of life with falls and injuries among older people in India
Scientific ReportsFalls and injuries and their consequences impact people’s quality of life (QoL), especially in older people. This study assesses the level of falls, injuries, and QoL and examines the linkages of QoL with falls, and injuries among older people in India ...
Anil Kumar Pal, Sanjay Kumar Pal
doaj +1 more source