Results 121 to 130 of about 2,042,710 (299)

The Relationship Between Individual Innovation Levels and Lifelong Learning Tendencies of Nurses From Different Generations

open access: yesSağlık ve Hemşirelik Yönetimi Dergisi
Aim: The research was conducted to determine the relationship between the innovativeness levels of nurses with X, Y and Z generation characteristics and their lifelong learning tendencies.
Özge Bahar Sertkaya, Gönül Bodur
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Theoretical and methodological approaches to the study of generations: a comparative analysis

open access: yesВестник Майкопского государственного технологического университета
. The article defines the concept of «generation», and analyzes the transformation of this concept at various stages of the development of generational theory.
V. S. Novikova
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Editorial

open access: yesIntergenerational Justice Review, 2019
In April 2019, Greta Thunberg made TIME Magazine’s 100 Most Influential People of 2019 list. The 16 year-old climate activist, who has also been nominated for a Nobel Peace Prize, started a movement that saw a multitude of student protests and school ...
Ann-Kristin Kölln   +4 more
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Kuşaklara göre Akademisyenlerin Yapay Zeka Kaygıları Üzerine Bir Değerlendirme

open access: yesCumhuriyet Üniversitesi İktisadi ve İdari Bilimler Dergisi
Bu çalışma, farklı kuşaklardaki akademisyenlerin gelişen ve çeşitlenen yapay zekâ (YZ) ile ilgili kaygılarını incelemeyi amaçlamaktadır. YZ teknolojilerinin hızla gelişmesi, her sektördeki ve her özellikteki çalışanda güvenlik, işini kaybetme, kültürel ...
Mustafa Özkan, Esra Gökçen Kaygısız
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

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